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NCT05894356: Paternal Clock
The Paternal Clock: Uncovering the Consequences of Advanced Paternal Age on Sperm DNA Fragmentation
trial testing Study chart review in Infertility, Male in 4,250 participants. Completed in 30 January 2024.
31 December 2023
Quick facts
| Lead sponsor | Clinique Ovo |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 4,250 |
| Start date | 10 June 2023 |
| Primary completion | 31 December 2023 |
| Estimated completion | 30 January 2024 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Study chart review
Conditions studied
- Infertility, Male — all drugs for Infertility, Male →
Sponsor
Clinique Ovo — full company profile →
Who can join
18 and older, male only, with Infertility, Male. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Sperm DNA fragmentation (SDF) serves as a marker for chromatin and DNA damage in sperm. Assessing sperm DNA integrity is crucial in male fertility evaluation since high levels of SDF are associated with a greater number of adverse reproductive outcomes, including an increased risk of miscarriage and birth defects. Recent research suggests that advanced paternal age (APA) may lead to DNA damage in sperm, however the precise age at which this risk becomes apparent has not yet been clearly defined, necessitating the identification of the point in time at which high SDF levels occur. With the help of this knowledge, male infertility can be diagnosed with greater accuracy, and infertile couples can receive appropriate care.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05894356
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Study chart review
Trials testing the same drug.
- NCT05737979 — Modified Rekovelle and Menopur Combination Protocol to Avoid Monitoring Before Day 10 of Stimulation · completed
Other recruiting trials for Infertility, Male
Currently open trials in the same condition.
- NCT06950203 — The Effect of Supplementation With Fish Oil (EPAX EVOLVE 05) on Sperm Quality · NA · recruiting
- NCT06539585 — Scanning the Meiotic Spindle in Assisted Reproductive Techniques to Assess Oocyte Quality · NA · active not recruiting
- NCT05514223 — Measuring Free Radicals in Human Sperm Cells Related to Microbiota and Lifestyle Factors · recruiting
- NCT06841861 — Spermatogonial Differentiation Via Testicular Organoid · Phase 1, PHASE2 · recruiting
- NCT05903859 — Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI) · Phase 3 · recruiting
Other Clinique Ovo trials
Trials by the same sponsor.
- NCT07286279 — Identifying Candidates for Limited Dissection at Microdissection TESE. · completed
- NCT07457684 — Comparison of Follitropin Delta and Follitropin Alfa in Combination With Menotropin · completed
- NCT07268235 — Timing of Oocyte Retrieval and Micro Testicular Sperm Extraction · completed
- NCT06502665 — Second Ovulation Induction · completed
- NCT06290921 — Ovulation Triggering 2 vs 3 Follicles · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05894356 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Clinique Ovo
- Last refreshed: 20 February 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05894356.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing