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NCT05892640
Low-Salt Diet Effect on Th17-Mediated Inflammation and Vascular Reactivity in Psoriasis
NA trial testing Low-Salt Diet in Psoriasis Vulgaris in 50 participants. Status unknown.
31 December 2023
Quick facts
| Lead sponsor | Josip Juraj Strossmayer University of Osijek |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 50 |
| Start date | 1 September 2022 |
| Primary completion | 31 December 2023 |
| Estimated completion | 30 June 2024 |
| Sites | 1 location across Croatia |
Drugs / interventions tested
- Low-Salt Diet
Conditions studied
- Psoriasis Vulgaris — all drugs for Psoriasis Vulgaris →
Sponsor
Josip Juraj Strossmayer University of Osijek
Who can join
Adults 18 to 69, any sex, with Psoriasis Vulgaris. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Psoriasis presents an independent cardiovascular risk factor characterized by chronic low-grade systemic inflammation and oxidative stress which altogether might lead to endothelial dysfunction. It has been reported that increased oxidative stress has a pivotal role in high dietary sodium-induced endothelial dysfunction. Previous studies on sodium accumulation in psoriatic skin lesions and the sodium-induced augmentation in Th17 immune response, raise the question on the complex interplay between sodium and psoriasis, especially in the context of cardiovascular morbidity. This study aimed to investigate the effect of a 2-week low-salt diet on endothelium-dependent and endothelium-independent cutaneous microvascular vasodilation and Th17-Mediated Inflammation in patients with psoriasis vulgaris.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Naturally derived bioactive compounds as precision modulators of immune and inflammatory mechanisms in psoriatic conditions.
Radu A, Tit DM, Endres LM, Radu AF, et al · · 2025 · cited 13× · PMID 39576422 · DOI 10.1007/s10787-024-01602-z -
Two-Week Low-Salt Diet Improves Acetylcholine-Induced Microvascular Dilation in Biologically Naïve Psoriasis Patients.
Krajina I, Štefanić M, Drenjančević I, Milić J, et al · · 2025 · cited 1× · PMID 40005022 · DOI 10.3390/nu17040693
Verify or expand the search:
- PubMed search for NCT05892640
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Low-Salt Diet
Trials testing the same drug.
- NCT02730780 — The Natriuretic Peptide System in African-Americans. · NA · completed
Other recruiting trials for Psoriasis Vulgaris
Currently open trials in the same condition.
- NCT07426120 — Efficacy and Safety of a Botanical Total Coumarin (TC) Cream in Treating Patients With Psoriasis Vulgaris (PLANTCOAT-III · Phase 3 · recruiting
- NCT07320872 — Correlation Between Vaspin Gene Polymorphism and Serum Vaspin Levels in Psoriasis Vulgaris · recruiting
- NCT06398106 — Proactive TDM Versus Standard Use of Biologics in Psoriasis · Phase 4 · recruiting
- NCT05185258 — Residual Disease MEMory in PSOriasis Skin During EnstiLAR® and Narrow-band Ultraviolet B Therapy: The MEMPSOLAR Study · Phase 4 · active not recruiting
- NCT04950218 — Prevalence and Risk Factors asSOciated With CArdiac comorbiDIty in psoriAsis · recruiting
Other Josip Juraj Strossmayer University of Osijek trials
Trials by the same sponsor.
- NCT07437729 — Glycocalyx and Oxidative Stress in Endothelial Function (Part 1) · recruiting
- NCT07451873 — Glycocalyx and Oxidative Stress in Endothelial Function (Part 2) · recruiting
- NCT06545812 — Immune Response During the Conservative and Minimal Invasive Treatment of Pain Caused by Lumbar Disc Herniation · NA · completed
- NCT06316271 — Endothelial Function in Prehypertension · not yet recruiting
- NCT06316284 — miRNA in Chronic Kidney Diseases · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05892640 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Josip Juraj Strossmayer University of Osijek
- Last refreshed: 9 June 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05892640.
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