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NCT05892510
Post-thrombectomy Intra-arterial Tenecteplase for Acute manaGement of Non-retrievable Thrombus and No-reflow in Emergent Stroke
Phase 2, PHASE3 trial testing Intra-arterial tenecteplase injection at the completion of thrombectomy in Ischemic Stroke, Acute in 462 participants. Currently enrolling.
30 August 2027
Quick facts
| Lead sponsor | University of Melbourne |
|---|---|
| Phase | Phase 2, PHASE3 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 462 |
| Start date | 1 June 2024 |
| Primary completion | 30 August 2027 |
| Estimated completion | 30 November 2027 |
| Sites | 13 locations across Australia |
Drugs / interventions tested
- Intra-arterial tenecteplase injection at the completion of thrombectomy — full drug profile →
- Placebo
Conditions studied
- Ischemic Stroke, Acute — all drugs for Ischemic Stroke, Acute →
- Cerebrovascular Disorders — all drugs for Cerebrovascular Disorders →
- Brain Disorder — all drugs for Brain Disorder →
- Central Nervous System Diseases — all drugs for Central Nervous System Diseases →
Sponsor
University of Melbourne
Who can join
18 and older, any sex, with Ischemic Stroke, Acute or Cerebrovascular Disorders. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Multicentre, prospective, Multi-arm Multi-stage (MAMS) seamless phase 2b/3 interventional randomized placebo-controlled double-blinded parallel-assignment (2 arms with 1:1 randomization) efficacy and safety trial to test intra-arterial tenecteplase at the completion of thrombectomy versus best practice in participants with anterior circulation LVO receiving mechanical thrombectomy within 24 hours of symptoms onset.
Publications & conference data
6 peer-reviewed publications reference this trial (live from Europe PMC):
-
Comprehensive Review of Tenecteplase for Thrombolysis in Acute Ischemic Stroke.
Wang L, Hao M, Wu N, Wu S, et al · · 2024 · cited 48× · PMID 38686848 · DOI 10.1161/jaha.123.031692 -
Hyperacute ischemic stroke care-Current treatment and future directions.
Campbell BC. · · 2024 · cited 18× · PMID 39096172 · DOI 10.1177/17474930241267353 -
Adjunctive Thrombolytics After Successful Endovascular Reperfusion: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Doheim MF, Mohammaden MH, Jumah A, Yang Q, et al · · 2025 · cited 6× · PMID 40799167 · DOI 10.1002/ana.70021 -
Adjunctive intra-arterial tenecteplase after successful endovascular thrombectomy in patients with large vessel occlusion stroke (POST-TNK): Study rationale and design.
Huang J, Guo C, Yang J, Shi X, et al · · 2025 · cited 6× · PMID 39345180 · DOI 10.1177/23969873241286983 -
Current perspectives on endovascular therapy for large core ischemic stroke.
Mutimer CA, Campbell BCV. · · 2025 · cited 1× · PMID 40527681 · DOI 10.1016/j.neurot.2025.e00622 -
Letter to the Editor, Regarding "Comparative Efficacy and Safety of Different Tenecteplase Doses With Alteplase in Acute Ischemic Stroke: A Systematic Review With Pairwise and Network Meta-Analysis to Determine the Optimal Dose" Recently Published by Waseem and Colleagues.
Frol S, Zupan M, Papanagiotou P. · · 2025 · PMID 41273017 · DOI 10.1002/brb3.71055
Verify or expand the search:
- PubMed search for NCT05892510
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05892510 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Melbourne
- Last refreshed: 25 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05892510.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing