Last reviewed · How we verify
NCT05891977: MITOS
Effect of Tomato Paste Consumption on the Microbiota-gut-brain Axis in Healthy Adults
NA trial testing Intervention A - Tomato paste in Microbiota in 47 participants. Completed in 4 December 2024.
4 December 2024
Quick facts
| Lead sponsor | University of Barcelona |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 47 |
| Start date | 25 October 2023 |
| Primary completion | 4 December 2024 |
| Estimated completion | 4 December 2024 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Intervention A - Tomato paste
- Intervention B - Control
Conditions studied
- Microbiota — all drugs for Microbiota →
- Cognitive Function — all drugs for Cognitive Function →
- Healthy Lifestyle — all drugs for Healthy Lifestyle →
Sponsor
University of Barcelona
Who can join
Adults 40 to 55, any sex, with Microbiota or Cognitive Function. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Tomatoes and tomato-based products could play an important role in modulating microbiota-gut-brain axis (MGBA) interactions due to their high content of fiber and phytochemicals. Phytochemical metabolites derived from the consumption of tomato-based products can act directly as neurotransmitters in the central nervous system, crossing the blood-brain barrier, or indirectly by modulating the MGBA. These metabolites can thus alter gut bacterial composition and brain biochemistry. Therefore, researchers propose a new interventional study to assess the impact of daily tomato consumption in the organism, and to evaluate the effect on the MGBA. The final aim of this study is to spread a message of the health benefits of tomato consumption for the general population.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Tomato Intake Improves Cognitive Performance and Modulates Functional Brain Networks in Healthy Adults: A Randomized Crossover Clinical Trial.
López-Solís R, Donat-Vargas C, Ramírez-Carrasco P, Gutiérrez-Romero RM, et al · · 2026 · PMID 42193265 · DOI 10.3390/antiox15050644
Verify or expand the search:
- PubMed search for NCT05891977
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05891977 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Barcelona
- Last refreshed: 25 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05891977.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing