Single-center Prospective Longitudinal Study of Taste in Patients With Cognitive Disorders at Different Stages of Severity (Isolated Cognitive Complaint, Minor or Major Neurocognitive Alzheimer-type Disorders) by Analysis of Gustatory Evoked Potentials (MAPEG 2)

NCT05888961 NA RECRUITING

The aim of the MAPEG 2 study is to explore gustatory function and to follow its evolution in the 4 following groups of participants: * Healthy subjects * Participants with isolated cognitive complaint * Participants with minor neurocognitive disorder * Participants with mild and moderate Alzheimer-type major neurocognitive disorders For this purpose, we want to compare the results of the following tests: * Subjective taste tests (tasting solutions, answering food preference questionnaires), * Gustatory evoked potential (GEP) parameters, recorded by electrodes placed on the scalp, * And nutritional parameters (hormones of food intake by blood test, measurement of the global body composition). Identifying and following the evolution of early taste disorders in case of cognitive disorders could improve the diagnosis of Alzheimer\'s disease in two ways: * To allow an early diagnosis of Alzheimer\'s disease, and thus improve its management, * To define groups of subjects at risk of developing Alzheimer\'s disease in later years.

Details

Lead sponsor	Centre Hospitalier Universitaire Dijon
Phase	NA
Status	RECRUITING
Enrolment	72
Start date	2023-06-12
Completion	2027-07

Conditions

• Cognitive Disorders

Interventions

• Blood samples
• Interviewing the subject and scales
• Neurocognitive evaluation
• Taste tests
• Computerized food preference questionnaires
• Nutritional status - body composition

Primary outcomes

• Amplitude of the gustatory evoked potentials — After a 2-hour fasting period
• Gustatory evoked potentials latency — After a 2-hour fasting period

Countries

France