Ketone Ester Supplementation and Nocturnal Blood Pressure

NCT05888506 NA COMPLETED

Cardiovascular disease (CVD) is the number one cause of death globally and high blood pressure (i.e., hypertension) is the leading modifiable risk factor for CVD and all-cause mortality. Advancing age is the primary risk factor for hypertension and CVD. Moreover, compared to younger adults, older adults exhibit reduced nocturnal dipping of blood pressure resulting in elevated nighttime blood pressure values, which are a better predictor of cardiovascular outcomes than daytime blood pressure. Intriguingly, recently published rodent data suggests that ketone supplementation protects against hypertension, blood vessel dysfunction, and kidney injury. Whether ketone supplementation provides vascular health benefits in humans remains to be determined. Therefore, the investigations seek to conduct an acute ketone supplementation study to determine whether ketone supplementation may restore a more healthy nighttime blood pressure phenotype in middle-aged and older adults. The investigations will also determine whether ketone supplementation influences nocturnal heart rate variability, a non-invasive of autonomic function that may be influenced by ketone supplementation in a manner that influences blood pressure.

Details

Lead sponsor	Georgia Southern University
Phase	NA
Status	COMPLETED
Enrolment	40
Start date	Tue Aug 01 2023 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Tue Oct 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Cardiovascular Diseases in Old Age
• Aging
• Cardiovascular Diseases
• Sleep

Interventions

• Ketone Ester
• Placebo

Countries

United States