21 and older, any sex, with Smoking Cessation. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Total Inhaled VolumePrimary· 5 minutes
Differences within participants in total inhaled volume in electronic cigarette puff topography during the pharmacokinetic portions of lab visit 1 and 2
Group
Value
95% CI
5% Nicotine E-cigarette
416.5
± 258.3
1.8% Nicotine E-cigarette
490.3
± 255.1
Participant Switch TrajectorySecondary· Week 6 of the Phase 2 period, approximately 8 weeks post-baseline
Switch trajectory: biochemically confirmed \[exhaled carbon monoxide\] complete switch, use of both e-cigarettes and cigarettes, use of only cigarettes, complete cessation \[non-use of e-cigarettes and cigarettes with biochemical confirmation\]
Group
Value
95% CI
5% Nicotine E-cigarette
10
1.8% Nicotine E-cigarette
6
5% Nicotine E-cigarette
10
1.8% Nicotine E-cigarette
13
5% Nicotine E-cigarette
3
1.8% Nicotine E-cigarette
0
5% Nicotine E-cigarette
1
1.8% Nicotine E-cigarette
0
Sponsor's own description
The study will be the first to assess the impact of nicotine concentration on compensatory puffing (total inhaled volume), nicotine delivery, and switch patterns (percent exclusive EC, dual cig-EC, and cig only users) with an explicit focus on AA and White smokers.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
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· recruiting
NCT07331519 — Integrating Smoking Cessation With Low-dose CT-screening for Lung Cancer
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· recruiting
NCT07210567 — Mindfulness-based Ecological Momentary Intervention for Smoking Cessation Among Cancer Survivors
· NA
· recruiting
NCT07129590 — Trauma-Informed Care for Smoking Cessation for Pregnancy
· NA
· recruiting
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Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Kansas Medical Center
Last refreshed: 10 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05887947.