NCT05886738

Investigating the Effect of Short-term Fasting on T Cell Metabolism, Function, and Phenotype in Obesity

Status unknown NA Last updated 2 June 2023

What this trial tests

NA trial testing Fasting in Obesity in 20 participants. Status unknown.

Timeline

1 June 2023

Primary endpoint
30 August 2023

30 August 2023

Quick facts

Lead sponsor	University of British Columbia
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	basic science
Enrollment	20
Start date	1 June 2023
Primary completion	30 August 2023
Estimated completion	30 August 2023

Drugs / interventions tested

• Fasting

Conditions studied

• Obesity — all drugs for Obesity →
• Fasting — all drugs for Fasting →
• T-Cell Dysfunction — all drugs for T-Cell Dysfunction →

Sponsor

University of British Columbia

Who can join

Adults 19 to 69, any sex, with Obesity or Fasting. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The immune system is made up of many types of immune cells, each of which play a specialized role in protecting against pathogens. T cells are a crucial part of the adaptive immune system, and receive signals from the body's metabolism which tell them whether they should become activated to respond to an infection or if they should stay in their resting state. In obesity, the body's metabolism shifts and these T cells become less effective at protecting against infection and instead start to increase inflammation which is involved in obesity-related health conditions. The investigators are conducting this study because the investigators are interested in understanding how fasting, which will alter the metabolic signals that T cells receive, might impact the types of T cells that are present and how they respond to activating signals. Additionally, the investigators are interested in understanding if these responses differ between T cells from individuals with obesity versus lean individuals.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Reversible histone deacetylase activity catalyzes lysine acylation.
   Tsusaka T, Najar MA, Schwarz B, Bohrnsen E, et al · · 2025 · cited 15× · PMID 40140626 · DOI 10.1038/s41589-025-01869-5
2. Altered immunometabolic response to fasting in humans living with obesity.
   Neudorf H, Sandilands RE, Ursel S, Shaba H, et al · · 2025 · cited 2× · PMID 40662191 · DOI 10.1016/j.isci.2025.112872
3. Metabolic responses to 48 h fasting and refeeding in adults with and without obesity.
   Sandilands R, Neudorf H, Ursel S, Shaba H, et al · · 2026 · PMID 41650389 · DOI 10.1139/apnm-2025-0447