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NCT05884528: RELY-CD
Assessment of Long-term Clinical Response to BoNT in Cervical Dystonia
trial testing CC BoNT/A in Cervical Dystonia in 270 participants. Completed in 31 July 2024.
31 May 2024
Quick facts
| Lead sponsor | Merz Therapeutics GmbH |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 270 |
| Start date | 8 July 2023 |
| Primary completion | 31 May 2024 |
| Estimated completion | 31 July 2024 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- CC BoNT/A — full drug profile →
- CF BoNT/A — full drug profile →
- CF to CC BoNT/A — full drug profile →
- CC to CF BoNT/A — full drug profile →
Conditions studied
- Cervical Dystonia — all drugs for Cervical Dystonia →
Sponsor
Merz Therapeutics GmbH — full company profile →
Who can join
Adults 18 to 64, any sex, with Cervical Dystonia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this retrospective, international, multi-center chart abstraction is to learn about the long-term impact of product-specific immunogenicity-related factors in different botulinum neurotoxin type A formulations in patients suffering from cervical dystonia. The main question it aims to answer is: Do complex-containing (CC) botulinum toxin formulations impact the long-term clinical outcome in cervical dystonia patients compared to a complex-free (CF) formulation? Researchers will compare differences observed in years 2 and 7 between two toxin groups, i.e., botulinum neurotoxins type A containing complexing proteins (CC) and without complexing proteins (CF).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Protocol and Demographics of the RELY-CD Study: Assessing Long-Term Clinical Response to Botulinum Neurotoxin in Cervical Dystonia.
Waeschle B, Lee JI, Kölsche T, Jansen R, et al · · 2025 · PMID 40278678 · DOI 10.3390/toxins17040180
Verify or expand the search:
- PubMed search for NCT05884528
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Cervical Dystonia
Currently open trials in the same condition.
- NCT07140874 — Zinc as an Adjunctive Therapy for Cervical Dystonia · Phase 2 · recruiting
- NCT06937931 — A Study of IPN10200 for the Treatment of Cervical Dystonia in Adults · Phase 2 · recruiting
Other Merz Therapeutics GmbH trials
Trials by the same sponsor.
- NCT06091020 — A Clinical Trial to Investigate Efficacy and Safety of NT 201 Injections Compared With Placebo Injections in Participant · Phase 2 · completed
- NCT06381999 — Validity and Inter-rater Reliability for Early Recognition of Spasticity Using the Decision Tree Tool · completed
- NCT05943860 — Efficacy and Tolerability of Pantovigar® Vegan in Female Subjects With Diffuse Hair Loss · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05884528 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Merz Therapeutics GmbH
- Last refreshed: 21 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05884528.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing