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NCT05883982
Intra-articular I-PRF Injections in Patients With Temporomandibular Joint Dysfunction
Phase 2 trial testing I-PRF injection in Temporomandibular Joint Disorders in 49 participants. Completed in 30 June 2025.
31 December 2024
Quick facts
| Lead sponsor | Hospital of the Ministry of Interior, Kielce, Poland |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 49 |
| Start date | 1 June 2023 |
| Primary completion | 31 December 2024 |
| Estimated completion | 30 June 2025 |
| Sites | 1 location across Poland |
Drugs / interventions tested
- I-PRF injection — full drug profile →
Conditions studied
- Temporomandibular Joint Disorders — all drugs for Temporomandibular Joint Disorders →
- Temporomandibular Joint Pain — all drugs for Temporomandibular Joint Pain →
Sponsor
Hospital of the Ministry of Interior, Kielce, Poland
Who can join
18 and older, any sex, with Temporomandibular Joint Disorders or Temporomandibular Joint Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of the study will be to analyze the results of injection treatment in patients diagnosed with temporomandibular joint dysfunction manifested by pain and/or limited jaw mobility. The treatment will consist in the administration of autologous blood products into the cavities of the temporomandibular joints.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Baseline Oral Behaviours in Relation to Follow-Up Temporomandibular Joint Disease Severity After Intra-Articular I-PRF: A Baseline-Adjusted Exploratory Cohort Study.
Sielski M, Chęciński M, Chęcińska K, Turosz N, et al · · 2026 · PMID 42194534 · DOI 10.3390/jcm15103575 -
Evolution and mechanistic insights of platelet-derived products in temporomandibular joint regeneration.
Lin C, Jin Y, Li D, Yang Q, et al · · 2026 · PMID 41646866 · DOI 10.3389/fcell.2026.1776592
Verify or expand the search:
- PubMed search for NCT05883982
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Temporomandibular Joint Disorders
Currently open trials in the same condition.
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- NCT06763419 — Internal Photobiomodulation For Management Of Temporomandibular Joint Internal Derangement · NA · recruiting
- NCT06721104 — Balance, TMJ, Social Adaptive Assessment in Individuals With Autism Spectrum Disorder · recruiting
- NCT06500390 — Temporomandibular Disorder in Use of Levonorgestrel Intrauterine System · NA · recruiting
- NCT06813040 — Efficacy of Repetitive Transcranial Magnetic Stimulation in Temporomandibular Disorders. · NA · recruiting
Other Hospital of the Ministry of Interior, Kielce, Poland trials
Trials by the same sponsor.
- NCT06530745 — PRP vs HA Intra-articular Injections in TMDs · Phase 4 · completed
- NCT06258798 — The Use of Artificial Intelligence in the Dental X-rays Analysis · completed
- NCT07311473 — Comprehensive Outcomes of Palatal TSADs Treatment · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05883982 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital of the Ministry of Interior, Kielce, Poland
- Last refreshed: 15 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05883982.
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