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NCT05878951
Examining the Effects of Intra-detrusor Botox at Time of HoLEP in Men With Overactive Bladder Symptoms
Phase 2, PHASE3 trial testing OnabotulinumtoxinA in Urinary Incontinence in 80 participants. Currently enrolling.
1 May 2026
Quick facts
| Lead sponsor | Northwestern University |
|---|---|
| Phase | Phase 2, PHASE3 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 80 |
| Start date | 13 July 2023 |
| Primary completion | 1 May 2026 |
| Estimated completion | 24 August 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- OnabotulinumtoxinA (ONABOTULINUMTOXINA) — full drug profile →
Conditions studied
- Urinary Incontinence — all drugs for Urinary Incontinence →
- Overactive Bladder Syndrome — all drugs for Overactive Bladder Syndrome →
- Overactive Bladder — all drugs for Overactive Bladder →
- Urologic Diseases — all drugs for Urologic Diseases →
Sponsor
Northwestern University
Who can join
Adults 18 to 89, male only, with Urinary Incontinence or Overactive Bladder Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The objective of our multi-center randomized single-blind study is to examine the safety and effect of intra-detrusor OnabotulinumtoxinA injections at the time of holium laser enucleation of the prostate (HoLEP) in men with overactive bladder symptoms with and without urge incontinence.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05878951
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Urinary Incontinence
Currently open trials in the same condition.
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Other Northwestern University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05878951 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Northwestern University
- Last refreshed: 20 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05878951.
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