NCT05878925 (NOSE) is a NA clinical trial of Aroma in Apnea of Prematurity, sponsored by University of Zurich.

Who is sponsoring NCT05878925?

NCT05878925 is sponsored by University of Zurich.

What drugs are being tested in NCT05878925?

Interventions in NCT05878925: Aroma, Placebo.

What condition does NCT05878925 study?

NCT05878925 studies Apnea of Prematurity, Prematurity, Infant, Premature, Diseases.

Is NCT05878925 still recruiting?

NCT05878925 is currently completed. Last updated 4 April 2025.

Last reviewed 2025-04-04 · How we verify

NCT05878925: NOSE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Nasal Olfactory Stimulation and Its Effect on Respiratory Drive in Preterm Infants

Completed NA Last updated 4 April 2025

What this trial tests

NA trial testing Aroma in Apnea of Prematurity in 80 participants. Completed in 24 January 2025.

Timeline

14 June 2023

Primary endpoint
24 January 2025

24 January 2025

Quick facts

Lead sponsor	University of Zurich
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	treatment
Enrollment	80
Start date	14 June 2023
Primary completion	24 January 2025
Estimated completion	24 January 2025
Sites	1 location across Switzerland

Drugs / interventions tested

Aroma
Placebo

Conditions studied

Apnea of Prematurity — all drugs for Apnea of Prematurity →
Prematurity — all drugs for Prematurity →
Infant, Premature, Diseases — all drugs for Infant, Premature, Diseases →

Sponsor

University of Zurich

Who can join

72 Hours and older, any sex, with Apnea of Prematurity or Prematurity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This trial analyzes the effect of an olfactory stimulation with vanilla or strawberry aroma compared to placebo on desaturations and bradycardia in preterm infants with apnea of prematurity. Infants on continuous positive airway pressure (CPAP) support will be included and the aroma will be applied to the inner surface of the CPAP mask using designated scent pens. The trial uses a cross-over design. Infants are randomised to begin the study with either aroma or placebo which will be applied into the breathing mask every 3 to 4 hours during 12 hours for each of the two intervention periods. Identically looking pens with either aroma or placebo are used and patients, parents, medical staff and the study team are blinded to this allocation. Infants are monitored with an oximetry sensor to measure peripheral oxygen saturation (SpO2) and pulse rate.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Apnea of Prematurity

Currently open trials in the same condition.

NCT06374147 — "Prapela® SVS Incubator Pad for Apnea of Prematurity · NA · recruiting
NCT07396103 — Efficacy of PIMUN by Reducing Intermittent Hypoxia Events · NA · recruiting
NCT06905496 — Apnea of Prematurity Results in Respiratory Distress and Cyanosis. Caffeine Citrate Can Treat It. · Phase 1 · active not recruiting
NCT05196646 — Detection of CardioRespiratory Events Using Acoustic Monitoring in Preterm Infants on CPAP · active not recruiting
NCT04430790 — Doxapram Therapy in Preterm Infants (DOXA Trial) · Phase 3 · recruiting

Other University of Zurich trials

Trials by the same sponsor.

NCT07485699 — Soy Processing and Food Allergy · NA · not yet recruiting
NCT07516912 — Evaluation of Free STI Testing Pilot Projects in Lucerne and Zurich, Switzerland · not yet recruiting
NCT07473115 — Individualized Analgesia in the Intensive Care Unit With a New Pain Assessment Bundle and Protocolized Analgesia Adjustm · not yet recruiting
NCT07524023 — Emotional-distress-based Integrated Care Programme in Patients With Stable COPD · NA · recruiting
NCT06481982 — Value of Advanced MRI Techniques in the Assessment of Endometriosis · withdrawn

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05878925 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Zurich
Last refreshed: 4 April 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05878925.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing