Who is sponsoring NCT05878054?

NCT05878054 is sponsored by Leiden University Medical Center.

What drugs are being tested in NCT05878054?

Interventions in NCT05878054: Proactive, integrated and personalised care.

What condition does NCT05878054 study?

NCT05878054 studies Complex Patient, Multimorbidity, Psychosocial Problem, Chronic Disease.

Is NCT05878054 still recruiting?

NCT05878054 is currently active, enrolled. Last updated 24 February 2026.

Last reviewed 2026-02-24 · How we verify

NCT05878054

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Pursuing the Triple Aim in Hotspotters: Identification and Integrated Care

Active, enrolled NA Last updated 24 February 2026

What this trial tests

NA trial testing Proactive, integrated and personalised care in Complex Patient in 41 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

2 August 2023

Primary endpoint
31 December 2026

31 December 2026

Quick facts

Lead sponsor	Leiden University Medical Center
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	other
Enrollment	41
Start date	2 August 2023
Primary completion	31 December 2026
Estimated completion	31 December 2026
Sites	1 location across Netherlands

Drugs / interventions tested

Proactive, integrated and personalised care

Conditions studied

Complex Patient — all drugs for Complex Patient →
Multimorbidity — all drugs for Multimorbidity →
Psychosocial Problem — all drugs for Psychosocial Problem →
Chronic Disease — all drugs for Chronic Disease →

Sponsor

Leiden University Medical Center

Who can join

18 and older, any sex, with Complex Patient or Multimorbidity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Hotspotters are patients with complex care needs, defined by problems in multiple life domains and high acute care use. These patients often receive mismatched care, resulting in overuse of care and increased healthcare costs. Reliable data on (cost-)effective interventions for these patients are scarce. The goal of this study is to assess the cost-effectiveness of pro-active and integrated care. This approach includes: an intake consultation with Positive Health; multidisciplinary meetings with physician, mental healthcare nurse, social worker and the patient; a personalised care plan and proactive care management. We aim to include 200 patients, divided over 20 primary care practices.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Hotspotters Project: a study protocol for a stepped wedge cluster RCT on the cost-effectiveness of 12-month proactive, integrated and personalised care for patients with problems on multiple life domains and high acute care use.
Tiemes V, Leming KA, Borgdorff H, Bruijnzeels MA, et al · · 2025 · cited 1× · PMID 40784776 · DOI 10.1136/bmjopen-2024-087940

Verify or expand the search:

Other recruiting trials for Complex Patient

Currently open trials in the same condition.

NCT04450225 — The Psychometric Properties of the Italian Version of the Reintegration to Normal Living Index in Complex Patients · recruiting

Other Leiden University Medical Center trials

Trials by the same sponsor.

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NCT07498738 — Making Diabetes Care Fit for Young Adults Living With Type 1 Diabetes: Observations, Reflections and Expert Opinions · NA · not yet recruiting
NCT06545292 — Microsampling for Therapeutic Drug Monitoring of Oral Oncolytics in Oncology Patients · NA · recruiting
NCT07021495 — SKIN Disease Profiling by an Exploratory, pRospective, Biomarker Study in dermatoloGY Practice (SKINERGY) · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05878054 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Leiden University Medical Center
Last refreshed: 24 February 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05878054.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing