Who is sponsoring NCT05877885?

NCT05877885 is sponsored by AdventHealth.

What drugs are being tested in NCT05877885?

Interventions in NCT05877885: Targeted Cognitive Training Intervention, General Cognitive Training Intervention.

What condition does NCT05877885 study?

NCT05877885 studies Major Depressive Disorder, Apathy.

Is NCT05877885 still recruiting?

NCT05877885 is currently recruiting now. Last updated 22 October 2025.

Last reviewed 2025-10-22 · How we verify

NCT05877885

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics

Recruiting now NA Last updated 22 October 2025

What this trial tests

NA trial testing Targeted Cognitive Training Intervention in Major Depressive Disorder in 84 participants. Currently enrolling.

Timeline

19 September 2025

Primary endpoint
1 November 2028

1 December 2028

Quick facts

Lead sponsor	AdventHealth
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	84
Start date	19 September 2025
Primary completion	1 November 2028
Estimated completion	1 December 2028
Sites	1 location across United States

Drugs / interventions tested

Targeted Cognitive Training Intervention
General Cognitive Training Intervention

Conditions studied

Major Depressive Disorder — all drugs for Major Depressive Disorder →
Apathy — all drugs for Apathy →

Sponsor

AdventHealth — full company profile →

Who can join

60 and older, any sex, with Major Depressive Disorder or Apathy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this randomized controlled trial is to evaluate the potential of a customized digital cognitive training intervention to target aspects of brain function in apathy of late-life depression and reduce symptoms of apathy and related cognitive and behavioral deficits. The investigators hypothesize that 4 weeks of a customized digital cognitive training program will lead to changes in brain connectivity, apathy severity, and cognitive control performance.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Harnessing digital health interventions to address the heterogeneity of depression: a systematic review.
Alsalloum G, Dalibalta S, Hadijat Y. · · 2025 · PMID 41341467 · DOI 10.3389/fdgth.2025.1654745

Verify or expand the search:

Other recruiting trials for Major Depressive Disorder

Currently open trials in the same condition.

NCT07219394 — Peer-Delivered Behavioral Activation in a CCBHC · NA · recruiting
NCT06705478 — Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disor · Phase 2 · recruiting
NCT06749392 — An Individual-specific Synchrony Signature · NA · recruiting
NCT07316803 — Group Intervention for Romantic Relationships in Young Adults With Severe Mental Illness · NA · recruiting
NCT07242105 — Optimizing Brain Excitability in Depression · NA · recruiting

Other AdventHealth trials

Trials by the same sponsor.

NCT07359352 — Surgical Care And Recovery With Laser Evaluation Trial (SCARLET) · NA · not yet recruiting
NCT07472127 — Professional Readiness Through Emotional Preparedness (PREP) · NA · not yet recruiting
NCT07357376 — Evaluating Suzetrigine for Pain Control Following TKA · Phase 3 · not yet recruiting
NCT07298018 — A Pilot Study of RISE for Nurse Managers Retreat · NA · recruiting
NCT07081542 — Comparative Analysis of Hearing Outcomes: Robotic vs. Manual Insertion of Cochlear Implants · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05877885 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by AdventHealth
Last refreshed: 22 October 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05877885.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing