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NCT05877781
PEA in Functional Dyspepsia
NA trial testing Palmitoylethanolamide in Dyspepsia and Other Specified Disorders of Function of Stomach in 100 participants. Currently enrolling.
1 January 2025
Quick facts
| Lead sponsor | Universitaire Ziekenhuizen KU Leuven |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 100 |
| Start date | 29 November 2021 |
| Primary completion | 1 January 2025 |
| Estimated completion | 1 March 2025 |
| Sites | 1 location across Belgium |
Drugs / interventions tested
- Palmitoylethanolamide — full drug profile →
Conditions studied
- Dyspepsia and Other Specified Disorders of Function of Stomach — all drugs for Dyspepsia and Other Specified Disorders of Function of Stomach →
Sponsor
Universitaire Ziekenhuizen KU Leuven — full company profile →
Who can join
Adults 18 to 70, any sex, with Dyspepsia and Other Specified Disorders of Function of Stomach. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this placebo controlled randomized double blind interventional study is to assess the effect of palmitoylethanolamide supplementation in patients with functional dyspepsia The main questions it aims to answer are: * The efficacy of PEA on functional dyspepsia symptoms measured using the LPDS questionnaire * The effect of PEA on duodenal mucosal permeability. Participants will receive an 8-week during treatment with PEA 3x400 mg per day or placebo 3 times per day.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Investigating Properties of Palmitoylethanolamide in Physiology and Disease: Far Beyond an Anti-Inflammatory Shield.
Veredice C, Turrini I, Pelanda H, Contaldo I, et al · · 2026 · PMID 41745090 · DOI 10.3390/diseases14020052
Verify or expand the search:
- PubMed search for NCT05877781
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Palmitoylethanolamide
Trials testing the same drug.
- NCT06063369 — PEA vs. Placebo for Major Depression · Phase 2 · unknown
- NCT05480072 — Endocannabinoids, Stress, Craving And Pain Effects Study · EARLY_PHASE1 · completed
- NCT05242718 — Immune Diversity Response to Oral Dosing of Nutritional Health Products in Healthy Participants · NA · completed
Other recruiting trials for Dyspepsia and Other Specified Disorders of Function of Stomach
Currently open trials in the same condition.
- NCT06482671 — Primary Care dySpEpsia rikkuNshiTo · Phase 3 · recruiting
- NCT05880199 — BSGM to Evaluate Patients With GI Symptoms · recruiting
Other Universitaire Ziekenhuizen KU Leuven trials
Trials by the same sponsor.
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- NCT06962137 — Phase II RAINSPOT: Zolbetuximab-Paclitaxel-Ramucirumab for CLDN18.2 Positive Gastro-esophageal Cancer · Phase 2 · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05877781 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universitaire Ziekenhuizen KU Leuven
- Last refreshed: 1 July 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05877781.
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