NCT05877521 is a Phase 2 clinical trial of MORE treatments in Chronic Pain, sponsored by Memorial Sloan Kettering Cancer Center.

Who is sponsoring NCT05877521?

NCT05877521 is sponsored by Memorial Sloan Kettering Cancer Center.

What drugs are being tested in NCT05877521?

Interventions in NCT05877521: MORE treatments, Standard of Care for Pain Management.

What condition does NCT05877521 study?

NCT05877521 studies Chronic Pain, Cancer Pain.

Is NCT05877521 still recruiting?

NCT05877521 is currently active, enrolled. Last updated 23 September 2025.

Last reviewed 2025-09-23 · How we verify

NCT05877521

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Mindfulness-oriented Recovery Enhancement (MORE) for Cancer Pain Relief

Active, enrolled Phase 2 Last updated 23 September 2025

What this trial tests

Phase 2 trial testing MORE treatments in Chronic Pain in 76 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

16 May 2023

Primary endpoint
16 May 2027

16 May 2027

Quick facts

Lead sponsor	Memorial Sloan Kettering Cancer Center
Phase	Phase 2
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	76
Start date	16 May 2023
Primary completion	16 May 2027
Estimated completion	16 May 2027
Sites	1 location across United States

Drugs / interventions tested

MORE treatments
Standard of Care for Pain Management

Conditions studied

Chronic Pain — all drugs for Chronic Pain →
Cancer Pain — all drugs for Cancer Pain →

Sponsor

Memorial Sloan Kettering Cancer Center — full company profile →

Who can join

18 and older, any sex, with Chronic Pain or Cancer Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to evaluate whether or not mindfulness-based interventions/MBIs may help reduce chronic pain in participants who have cancer-related chronic pain. MBIs are therapeutic programs that use mindfulness meditation practices to help people focus on the present moment, as well as encourage acceptance of thoughts, emotions, and body sensations. The researchers think that an MBI treatment called Mindfulness-oriented Recovery Enhancement (MORE) may help people who are experiencing cancer-related chronic pain.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Mindfulness-Oriented Recovery Enhancement for Cancer Pain Relief: Pilot Randomized Controlled Trial.
Bryl KL, Hanley AW, Baser RE, Desai K, et al · · 2026 · PMID 41490669 · DOI 10.1016/j.jpainsymman.2025.12.024

Verify or expand the search:

Other recruiting trials for Chronic Pain

Currently open trials in the same condition.

NCT07491549 — The Effect of Pain Education Group Therapy and Its Impact on Chronic Pain, Kinesiophobia, and Physical Activity · NA · recruiting
NCT07425691 — SPACE for Youth With Chronic Pain · recruiting
NCT07103135 — Optimizing Accelerated TMS for Chronic Pain With Thompson Sampling · Phase 1 · recruiting
NCT06219408 — CIH Stepped Care for Co-occurring Chronic Pain and PTSD · NA · recruiting
NCT07270406 — Healthy Behaviors for Insomnia Prevention in People With HIV and Ongoing Pain · NA · recruiting

Other Memorial Sloan Kettering Cancer Center trials

Trials by the same sponsor.

NCT07566377 — Cord Blood Transplantation in Children and Young Adults With Blood Cancer · Phase 2 · recruiting
NCT07507643 — A Study of Methylprednisolone in People Having Liver Surgery · Phase 3 · recruiting
NCT07483307 — A Study of the Impact of Endocrine Therapy on Surgical Outcomes in People With Breast Cancer · Phase 2 · recruiting
NCT07459673 — HERizon-Breast: A ctDNA-Guided Adaptive Study of Sequential Anti-HER2 Therapies and CNS Prophylaxis to Induce Long-Term · Phase 2 · recruiting
NCT07449195 — A Study Comparing Two Optical Coherence Tomography Devices in People With Ocular Tumors · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05877521 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Memorial Sloan Kettering Cancer Center
Last refreshed: 23 September 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05877521.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing