NCT05874089 (DELong#3) is a NA clinical trial of VSL#3® in Long COVID, sponsored by Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico.

Who is sponsoring NCT05874089?

NCT05874089 is sponsored by Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico.

What drugs are being tested in NCT05874089?

Interventions in NCT05874089: VSL#3®, Placebo.

What condition does NCT05874089 study?

NCT05874089 studies Long COVID.

Is NCT05874089 still recruiting?

NCT05874089 is currently status unknown. Last updated 24 May 2023.

Last reviewed 2023-05-24 · How we verify

NCT05874089: DELong#3

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

VSL#3® vs Placebo in the Treatment of Fatigue and Other Symptoms in Long Covid (DELong#3)

Status unknown NA Last updated 24 May 2023

What this trial tests

NA trial testing VSL#3® in Long COVID in 96 participants. Status unknown.

Timeline

3 November 2022

Primary endpoint
3 September 2023

3 November 2023

Quick facts

Lead sponsor	Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	96
Start date	3 November 2022
Primary completion	3 September 2023
Estimated completion	3 November 2023
Sites	1 location across Italy

Drugs / interventions tested

VSL#3®
Placebo

Conditions studied

Long COVID — all drugs for Long COVID →

Sponsor

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Who can join

Adults 18 to 65, any sex, with Long COVID. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to evaluate the effectiveness of VSL#3® in reducing Fatigue and other symptoms in Long Covid Syndrome compared to placebo.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Exploring the Potential of Dietary Supplements to Alleviate Pain Due to Long COVID.
Marchesi N, Allegri M, Bruno GM, Pascale A, et al · · 2025 · cited 2× · PMID 40219044 · DOI 10.3390/nu17071287
The Role of VSL#3® in the Treatment of Fatigue and Other Symptoms in Long Covid-19 Syndrome: a Randomized, Double-blind, Placebo-controlled Pilot Study (DELong#3)
Marinoni B, Rimondi A, Bottaro F, Ciafardini C, et al · · 2023 · cited 1× · DOI 10.1101/2023.06.28.23291986

Verify or expand the search:

Other trials of VSL#3®

Trials testing the same drug.

NCT03586622 — One Year Home Monitoring and Treatment of IBS Patients · NA · unknown
NCT03415711 — PRObiotic VSL#3® for Maintenance of Clinical and Endoscopic REMission in Ulcerative Colitis · NA · terminated

Other recruiting trials for Long COVID

Currently open trials in the same condition.

NCT05931497 — Sauna for Long Covid · NA · recruiting
NCT06452095 — Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial - Effect of Hyperbaric Oxygen Therapy fo · NA · recruiting
NCT07316127 — Immunoadsorption in Autoimmune Long COVID · Phase 2 · recruiting
NCT07435805 — Long-Term Health Effects of Previous COVID-19 in Patients Undergoing Preoperative Anesthesia Evaluation · recruiting
NCT07278206 — Brain Stimulation in Long COVID · NA · recruiting

Other Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico trials

Trials by the same sponsor.

NCT07492433 — Risk Factors, Incidence, and Clinical Impact of Intraluminal Thrombosis Following FET and TEVAR · not yet recruiting
NCT07402174 — EIT- Guided Lung Recruitment in pARDS · NA · not yet recruiting
NCT07234097 — The Influence of Music on perceiVed paIn and leVels of Anxiety whiLe unDergoing transperIneal Prostate Biopsy: the VIVAL · NA · not yet recruiting
NCT07317193 — DEFINING THE GENETIC DRIVERS OF ADULT-ONSET CHOLESTATIC LIVER DISEASE · NA · recruiting
NCT07487961 — Assess Abdominal Aortic Diameter in Females · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05874089 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Last refreshed: 24 May 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05874089.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing