Last reviewed · How we verify
NCT05870787: MEDIATOR
iMproving thE DIagnostics And Treatment Of ceRvical Precancer
trial testing Swede score colposcopy in Cervical Dysplasia in 929 participants. Completed in 13 December 2024.
6 December 2024
Quick facts
| Lead sponsor | University of Aarhus |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 929 |
| Start date | 1 March 2023 |
| Primary completion | 6 December 2024 |
| Estimated completion | 13 December 2024 |
| Sites | 7 locations across Denmark |
Drugs / interventions tested
- Swede score colposcopy
Conditions studied
- Cervical Dysplasia — all drugs for Cervical Dysplasia →
- Cervical Disease — all drugs for Cervical Disease →
- Cervical Lesion — all drugs for Cervical Lesion →
- Cervical Cancer — all drugs for Cervical Cancer →
Sponsor
University of Aarhus
Who can join
Adults 23 to 99, female only, with Cervical Dysplasia or Cervical Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Cervical cancer screening is important as it enables identification of women at increased risk of the disease, but high-quality diagnostics of screen-positive women and effective treatment of those with precancer are critical in preventing progression to cancer. With the current transition from cytology-based to primary human papillomavirus (HPV)-screening and a growing proportion of HPV-vaccinated women, diagnostics of screen-positive women will become more challenging in the decades to come. Thus, there is a need to explore how to improve diagnostics while ensuring a low number of unnecessary procedures such as colposcopy and the collection of multiple cervical biopsies. The overall purposes are: Purpose 1: To investigate the diagnostic accuracy of cervical precancer when using a colposcopic scoring system in the diagnostic work-up of screen-positive women. Purpose 2: To investigate the performance of a colposcopic scoring system to identify women without cervical precancer in whom collection of biopsies can be safely omitted.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Assessment of a colposcopic scoring system (Swedescore) to reduce the number of cervical biopsies: a protocol for a clinical multicentre non-randomised intervention study in Denmark.
Knudsen AS, Randrup TH, Kesmodel US, Booth B, et al · · 2024 · cited 2× · PMID 39675832 · DOI 10.1136/bmjopen-2024-085382
Verify or expand the search:
- PubMed search for NCT05870787
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Cervical Dysplasia
Currently open trials in the same condition.
- NCT05640700 — Vaginal Microbiome and HPV Pre-malignant and Cervical Dysplasia · recruiting
- NCT06452004 — Validation of Artificial Intelligence as Decision Support System in VIA (PRESCRIP-TEC) · NA · active not recruiting
- NCT05606133 — Circulating Human Papilloma Virus (HPV) DNA for the Screening and Surveillance of Gynecologic Cancers · NA · recruiting
- NCT05774561 — Role of Liquid Biopsies in HPV-associated Cancer Treatment Monitoring · recruiting
- NCT05051722 — Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer · recruiting
Other University of Aarhus trials
Trials by the same sponsor.
- NCT07209540 — European LUpuS Inception-Cohort Developing initiATivE · not yet recruiting
- NCT07317401 — Investigating the Effects of Intermittent Hypoxia-Hyperoxia Treatment (IHHT) in People With Post-Viral Myalgic Encephalo · NA · not yet recruiting
- NCT07531966 — Vascular Complications After Kidney Transplantation · recruiting
- NCT07528339 — Prospective RegIstry for Oncologic Reirradiation (PRIOR-DK) · not yet recruiting
- NCT07451028 — Effect of an Oral Neuromuscular Training Device on Dysphagia · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05870787 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Aarhus
- Last refreshed: 10 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05870787.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing