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NCT05870215: PRISMA
Phenotyping Responses to Systemic Corticosteroids in the Management of Asthma Attacks
trial testing Visit 1: Clinical exam and questionnaires in Asthma in 78 participants. Completed in 13 June 2024.
18 April 2024
Quick facts
| Lead sponsor | Université de Sherbrooke |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 78 |
| Start date | 1 September 2022 |
| Primary completion | 18 April 2024 |
| Estimated completion | 13 June 2024 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Visit 1: Clinical exam and questionnaires
- Visit 1: Respiratory physiology
- Visit 1: Inflammometry
- Visit 2: Clinical exam and questionnaires
- Visit 2: Respiratory physiology
- Visit 2: Inflammometry
- Visit 3: e-mail
Conditions studied
- Asthma — all drugs for Asthma →
Sponsor
Université de Sherbrooke — full company profile →
Who can join
12 and older, any sex, with Asthma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This observational study compares the phenotypic variability (clinical and biological) in treatment response to systemic corticosteroids according to the blood eosinophil count and FeNO in physician-diagnosed ≥12-year-old asthmatics presenting with an asthma attack and healthy controls. Multimodal clinical and translational assessments will be performed on 50 physician-diagnosed, ≥12-year-old asthma patients presenting with an asthma attack and 12 healthy controls. These will include a blood eosinophil count, FeNO, and testing for airway infection (conventional sputum cultures and POC nasopharyngeal swabs). People with asthma will be assessed on day 0 and after a 7-day corticosteroid course, with in-home monitoring performed in between.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Phenotyping the responses to systemic corticosteroids in the management of asthma attacks (PRISMA).
Celis-Preciado C, Leclerc S, Duval M, Cliche DO, et al · · 2025 · cited 15× · PMID 39947666 · DOI 10.1183/13993003.02391-2024 -
Phenotyping the Responses to Systemic Corticosteroids in the Management of Asthma Attacks (PRISMA): protocol for an observational and translational pilot study.
Celis-Preciado CA, Leclerc S, Duval M, Cliche DO, et al · · 2023 · cited 8× · PMID 37940357 · DOI 10.1136/bmjresp-2023-001932 -
Development and validation of a UHPLC-MS/MS method for the quantification of total conjugated 3-bromotyrosine and investigation of its association with asthma severity.
Gamrani M, Farjallah A, Kpaossou FM, Cliche D, et al · · 2026 · PMID 41997677 · DOI 10.1016/j.aca.2026.345450
Verify or expand the search:
- PubMed search for NCT05870215
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05870215 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Université de Sherbrooke
- Last refreshed: 21 June 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05870215.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing