Who is sponsoring NCT05865899?

NCT05865899 is sponsored by Istituto Ortopedico Rizzoli.

What drugs are being tested in NCT05865899?

Interventions in NCT05865899: valgus producing medial opening wedge high tibial osteotomy.

What condition does NCT05865899 study?

NCT05865899 studies Knee Osteoarthritis, Cartilage Degeneration, Malalignment, Bone.

Is NCT05865899 still recruiting?

NCT05865899 is currently completed. Last updated 17 January 2025.

Last reviewed 2025-01-17 · How we verify

NCT05865899: HTO-IOR

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Impact of High Tibial Osteotomy in Preventing Degenerative Disease Progression in Medial Knee Osteoarthritis.

Completed NA Last updated 17 January 2025

What this trial tests

NA trial testing valgus producing medial opening wedge high tibial osteotomy in Knee Osteoarthritis in 50 participants. Completed in 3 December 2024.

Timeline

17 May 2021

Primary endpoint
22 March 2023

3 December 2024

Quick facts

Lead sponsor	Istituto Ortopedico Rizzoli
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	50
Start date	17 May 2021
Primary completion	22 March 2023
Estimated completion	3 December 2024
Sites	1 location across Italy

Drugs / interventions tested

valgus producing medial opening wedge high tibial osteotomy

Conditions studied

Knee Osteoarthritis — all drugs for Knee Osteoarthritis →
Cartilage Degeneration — all drugs for Cartilage Degeneration →
Malalignment, Bone — all drugs for Malalignment, Bone →

Sponsor

Istituto Ortopedico Rizzoli — full company profile →

Who can join

Adults 40 to 65, any sex, with Knee Osteoarthritis or Cartilage Degeneration. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

High tibial osteotomy (HTO) surgical procedure can lead to clinically significant improvements in the cartilage and in subchondral bone quality, with a slow down of the osteoarthritis (OA) progression. Aim of the project is to: (i) clinically validate a 3D planned HTO surgical approach, through a quantitative grading of OA progression in a prospective randomized case-control clinical trial; (ii) correlate the internal knee loads with the changes assessed in cartilage and subchondral bone status to verify the hypothesis that HTO induced mechanical changes are associated with clinically significant OA improvements; (iii) relate imaging data with cartilage and subchondral bone mechanical properties, in order to classify OA progression in a more sensitive manner and allow a more precise diagnosis of the pathology stage.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Altered motor function during daily activities in patients eligible for high tibial osteotomy is primarily driven by knee varus deformity.
Valente G, Grenno G, Benedetti MG, Dal Fabbro G, et al · · 2025 · cited 2× · PMID 40246300 · DOI 10.1302/2633-1462.64.bjo-2024-0189.r1
High tibial osteotomy effectively restores motor function during daily activities in patients with knee osteoarthritis and varus deformity.
Valente G, Grenno G, Dal Fabbro G, Grassi A, et al · · 2025 · cited 1× · PMID 40959213 · DOI 10.1002/jeo2.70410

Verify or expand the search:

Other recruiting trials for Knee Osteoarthritis

Currently open trials in the same condition.

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Other Istituto Ortopedico Rizzoli trials

Trials by the same sponsor.

NCT07590882 — Evaluation of Return to Sports Activity After Periacetabular Osteotomy: An Observational Study · enrolling by invitation
NCT07021222 — Multifactorial Strategies for the Prevention of the Risks of Ulceration in Patients Affected by Diabetic Foot (DARE-DiaF · NA · recruiting
NCT07360964 — Clear Cell Chondrosarcoma in Italy · NA · active not recruiting
NCT07140367 — "Transarterial Microembolization (TAME) in Inflammatory Knee Pathology" · recruiting
NCT07102875 — Ready to Sail 2: A Pilot Study of Sail-Assisted Telerehabilitation in Rare Skeletal Diseases · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05865899 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Istituto Ortopedico Rizzoli
Last refreshed: 17 January 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05865899.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing