NCT05862753

Duration and Depth of Anesthesia Induced by a Bolus of Etomidate

Completed NA Last updated 17 May 2023

What this trial tests

NA trial testing induction by Etomidate bolus in Anesthesia in 18 participants. Completed in 20 April 2022.

Timeline

11 January 2022

Primary endpoint
20 April 2022

20 April 2022

Quick facts

Lead sponsor	Erasme University Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	other
Enrollment	18
Start date	11 January 2022
Primary completion	20 April 2022
Estimated completion	20 April 2022
Sites	1 location across Belgium

Drugs / interventions tested

• induction by Etomidate bolus — full drug profile →

Conditions studied

• Anesthesia — all drugs for Anesthesia →

Sponsor

Erasme University Hospital

Who can join

Adults 18 to 74, any sex, with Anesthesia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Induction of general anesthesia requires to be safe and to ensure a proper level of anesthesia. A proper anesthesia is sufficient to guarantee loss of consciousness and amnesia and without being too depth leading to a electroencephalogram (EEG) with burst suppression. The depth of anesthesia is monitored by the bispectral index analyse of the EEG, this allows to detect any under- or over-dose of anesthesia. The monitoring works with an unknown algorithm (patent), which evaluate the state of consciousness in the patient.

Etomidate and propofol are commonly use to ensure general anesthesia. Actually, really few litterature has objective informations about the monitoring of Etomidate. The few existant are the old ones and has just a clinical evaluation of the depth of anesthesia (loss of consciousness, loss of breathing, loss of palpebral reflex). Except the fact that these clinical evaluations come from the brain stem, and in fact are not reliable to assess the cortical activity which is reduced by etomidate.

Therefore, some anesthetists are fearful that etomidate is not sufficient to ensure a proper anesthesia to intubate the patient.

This interventionnal study has two purpose. Firstly, a survey will be conduct about the habits and beliefs when use of etomidate.

Secondly, a prospective study will be conduct to monitore with the bispectral index the depth and duration of anesthesia with etomidate.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.