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Testing Experimental Anti-cancer Drug SLC-391 With an Approved Immunotherapy Drug, Pembrolizumab, for Advanced Lung Cancers
SLC-391 is a novel, potent and specific small molecule inhibitor of receptor tyrosine kinase AXL with desirable potency and pharmaceutical properties. The study is being done to evaluate the safety and pharmacokinetic (PK) profile of SLC-391 in combination with pembrolizumab in participants with non-small cell lung cancer (NSCLC). Each treatment cycle lasts 21 days. Participants will swallow SLC-391 pills two times every day. Participants will get pembrolizumab intravenously (IV) from the study site staff on the first day of every cycle. This study has 2 parts. The first part will determine the recommended dose of SLC-391 in combination with pembrolizumab. The second part wants to find out if the combination of SLC-391 and pembrolizumab can help stop NSCLC tumours from growing or spreading.
Details
| Lead sponsor | SignalChem Lifesciences Corporation |
|---|---|
| Phase | PHASE1, PHASE2 |
| Status | TERMINATED |
| Enrolment | 36 |
| Start date | Wed May 31 2023 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Mon Dec 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Lung Cancer, Nonsmall Cell
- Lung Cancer Stage IV
- Lung Cancer Metastatic
Interventions
- SLC-391
- pembrolizumab
Countries
Canada, United States