NCT05859906

The Effect of Two Different Intra-abdominal Pressure Applications on "Mechanical Power" in Laparoscopic Cholecystectomy

Status unknown Last updated 16 May 2023

What this trial tests

trial testing mechanical power measurement in Ventilator-induced Lung Injury in 200 participants. Status unknown.

Timeline

15 May 2023

Primary endpoint
15 August 2023

15 October 2023

Quick facts

Lead sponsor	Ayse Ulgey
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	200
Start date	15 May 2023
Primary completion	15 August 2023
Estimated completion	15 October 2023
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

• mechanical power measurement

Conditions studied

• Ventilator-induced Lung Injury — all drugs for Ventilator-induced Lung Injury →

Sponsor

Ayse Ulgey

Who can join

Adults 18 to 75, any sex, with Ventilator-induced Lung Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In laparoscopic surgeries; a trocar is inserted through a small incision and an intervention is made into the peritoneal cavity. Approximately 3-4 liters of carbon dioxide (CO2) insufflation (inflating the abdominal cavity with carbon dioxide gas) is applied and the intra-abdominal pressure is adjusted to 10-20 mmHg. Laparoscopic cholecystectomy operation is routinely performed with 12 mmHg and 14 mmHg pressures in our operating room, and the preferred pressure value is; It is determined by the surgical team to be the most appropriate value for the patient and the operation. Both pressure values applied to the patients intraoperatively are within safe ranges.

The mechanical power of ventilation (MP) is the amount of energy transferred per unit time from the mechanical ventilator to the respiratory system. Although this energy is mainly used to overcome airway resistance, some of it directly affects the lung tissue, potentially causing ventilator induced lung injury (VILI). To prevent ventilator-associated lung injury, it requires the mechanical ventilator to be adjusted so that the least amount of energy is transferred to the respiratory system per unit time for each patient. In the results obtained in the published studies; increased mechanical strength has been associated with increased in-hospital mortality, higher hospital stay and higher ICU follow-up requirement.

The aim of this study is to investigate the effect of two different intra-operative intra-abdominal pressure levels applied to patients who underwent laparoscopic cholecystectomy under general anesthesia on 'Mechanical Power (MP)'.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.