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NCT05857774: RESPIRE
Respiratory Muscle Structure and Function in Mechanically Ventilated Patients and Long-term Outcomes
trial testing Sonographic measurements in Mechanical Ventilation Complication in 230 participants. Currently enrolling.
31 December 2025
Quick facts
| Lead sponsor | University Health Network, Toronto |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 230 |
| Start date | 27 April 2023 |
| Primary completion | 31 December 2025 |
| Estimated completion | 30 June 2026 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Sonographic measurements
- Physiological measurements
- Biological measurements
Conditions studied
- Mechanical Ventilation Complication — all drugs for Mechanical Ventilation Complication →
- Diaphragm Injury — all drugs for Diaphragm Injury →
- Lung Injury — all drugs for Lung Injury →
- Respiratory Insufficiency — all drugs for Respiratory Insufficiency →
Sponsor
University Health Network, Toronto
Who can join
18 and older, any sex, with Mechanical Ventilation Complication or Diaphragm Injury. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Air is normally pumped in and out of the lungs by the muscles that contribute to inhalation and exhalation, called the respiratory muscles. The abdominal muscles help by forcing air out of your lungs during exhalation; whereas the diaphragm, the main muscle used for breathing, contracts to get air into the lungs during inhalation. With mechanical ventilation, respiratory muscles are able to rest and recover while the breathing machine takes over; however, this may cause respiratory muscle weakness. Patients who develop weakness of these muscles may require more assistance from the ventilator and take longer to recover their ability to breathe without assistance. The impact of this phenomenon on long-term outcomes is uncertain. The RESPIRE study is designed to characterize how respiratory muscles change during mechanical ventilation and to evaluate the impact on long term quality of life. An additional objective of this study is to examine novel measures obtained from automated functions of a ventilator, that may better predict success from weaning from mechanical ventilation.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05857774
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Mechanical Ventilation Complication
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Other University Health Network, Toronto trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05857774 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Health Network, Toronto
- Last refreshed: 21 May 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05857774.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing