NCT05855954

Application of CLCVP Technique in Early Intervention of CSA-AKI

Recruiting now NA Last updated 30 May 2025

What this trial tests

NA trial testing controlled low central venous pressure technique (CLCVP) in Acute Kidney Injury in 200 participants. Currently enrolling.

Timeline

1 May 2023

Primary endpoint
31 August 2025

30 December 2025

Quick facts

Lead sponsor	Nanjing First Hospital, Nanjing Medical University
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	200
Start date	1 May 2023
Primary completion	31 August 2025
Estimated completion	30 December 2025
Sites	1 location across China

Drugs / interventions tested

• controlled low central venous pressure technique (CLCVP)

Conditions studied

• Acute Kidney Injury — all drugs for Acute Kidney Injury →

Sponsor

Nanjing First Hospital, Nanjing Medical University

Who can join

18 and older, any sex, with Acute Kidney Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this clinical trial is to learn about in postoperative acute kidney injury in cardiac surgery. The main questions it aims to answer are:

1. Controlled low central venous pressure (CLCVP) technique can reduce the occurrence of cardiac surgery-associated acute kidney injury (CSA-AKI) by reducing venous congestion and increasing renal perfusion pressure.
2. CLCVP technique does not increase the risk of postoperative cognitive dysfunction (POCD) during cardiac surgery.

Participants who are assigned to the intervention group will receive CLCVP technique. Specific methods are as follows: First,20min after the end of cardiopulmonary bypass, on the basis of ensuring that the mean arterial pressure (MAP) ≥ 60mmHg, the patients will accept dorsal elevated position. After that, if the patient's central venous pressure (CVP) is less than 10mmHg, nitroglycerin will be pumped at 0.2ug/ (kg \* min). If the patient's CVP is still greater than or equal 10mmHg, we increase the dose by 0.2ug/ (kg \* min) and pump again for 5min, and the like. Until the patient's CVP is less than 10mmHg or the dose of nitroglycerin increases to 1ug/ (kg \* min), the current dose is maintained until the end of surgery.

If participants are assigned to the control group, no intervention measures will be taken.

The researchers will compare the intervention group with the control group to see the occurrence of CSA-AKI and POCD after cardiac surgery.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Prediction of intraoperative acquired pressure injury in elderly cardiac surgery patients via machine learning: model development with the MIMIC-IV and external validation.
   Cheng Y, Li L, Zhang J, Zhou J, et al · · 2025 · PMID 41466406 · DOI 10.1186/s12911-025-03325-9