Last reviewed · How we verify
NCT05853913
Acute Exercise on Brain Insulin Sensitivity
NA trial testing Exercise in Aging in 16 participants. Completed in 25 March 2025.
20 March 2025
Quick facts
| Lead sponsor | Rutgers, The State University of New Jersey |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 16 |
| Start date | 11 May 2023 |
| Primary completion | 20 March 2025 |
| Estimated completion | 25 March 2025 |
| Sites | 4 locations across United States |
Drugs / interventions tested
- Exercise
Conditions studied
- Aging — all drugs for Aging →
- Obesity — all drugs for Obesity →
- Insulin Resistance — all drugs for Insulin Resistance →
- Cognition — all drugs for Cognition →
Sponsor
Rutgers, The State University of New Jersey
Who can join
Adults 40 to 80, any sex, with Aging or Obesity. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Dementia is a leading cause of death in the United States among aging adults. Brain insulin resistance has emerged as a pathologic factor affecting memory, executive function as well as systemic glucose control. Regular aerobic exercise decreases Alzheimer's Disease (AD) risk, in part, through changes in brain structure and function. However, there is limited data available on how exercise impacts brain insulin resistance in aging. This study will test the effect of acute exercise on brain insulin sensitivity in middle-aged to older adults. The study will also examine cognition and cardiometabolic health in relation to brain insulin sensitivity.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Effect of a single exercise bout on fasting cerebral blood flow and brain insulin sensitivity in middle-aged to older adults.
Malin SK, Shah AM, Berri MS, Zald DH, et al · · 2026 · cited 2× · PMID 41439617 · DOI 10.1113/ep093333 -
A Single Bout of Aerobic Exercise Increases Neuronal Extracellular Vesicle-Derived Insulin Signaling Biomarkers in Adults With Cardiometabolic Risk.
Malin SK, Battillo DJ, Beeri MS, Mustapic M, et al · · 2026 · PMID 41876945 · DOI 10.1002/cph4.70131
Verify or expand the search:
- PubMed search for NCT05853913
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Aging
Currently open trials in the same condition.
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Other Rutgers, The State University of New Jersey trials
Trials by the same sponsor.
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- NCT07525011 — Comparative Study of Denture Fabrication Techniques · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05853913 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rutgers, The State University of New Jersey
- Last refreshed: 21 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05853913.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing