Last reviewed · How we verify
NCT05853536
In Silico Trials of Surgical Interventions
trial in Cardiovascular Diseases in 13,977,257 participants. Status unknown.
1 August 2023
Quick facts
| Lead sponsor | University of Leicester |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 13,977,257 |
| Start date | 1 August 2019 |
| Primary completion | 1 August 2023 |
| Estimated completion | 1 August 2024 |
| Sites | 1 location across United Kingdom |
Conditions studied
- Cardiovascular Diseases — all drugs for Cardiovascular Diseases →
Sponsor
University of Leicester
Who can join
18 and older, any sex, with Cardiovascular Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The project aims to establish a database of cardiovascular patients using HES and linked mortality data. This database will be used to model trials in silico with the aim of informing the design of future cardiovascular trials in the United Kingdom.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Study design for an emulated trial of a 2 arm, parallel, stratified, adaptive, RCT of CABG versus PCI in people requiring myocardial revascularization at high risk (High-Risk REVASC).
Liao W, Rashid M, Brookes CL, Barber S, et al · · 2026 · PMID 41638385 · DOI 10.1016/j.ahj.2026.107368 -
Validation of “Days Alive and out of Hospital” as an Outcome Measure After Coronary Artery Bypass Graft Surgery, Acute Coronary Syndrome and Heart Failure Hospitalisation
Grant R, Liao W, Miksza J, Roman M, et al · · 2024 · DOI 10.1101/2024.02.12.24302587
Verify or expand the search:
- PubMed search for NCT05853536
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University of Leicester trials
Trials by the same sponsor.
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- NCT07014579 — Using Heart Electrical Signals to Study How Well Treatments Prevent Dangerous Heart Rhythms in Active People · not yet recruiting
- NCT06955663 — Exercise Support and Rehabilitation for Patients After Spontaneous Coronary Artery Dissection · NA · recruiting
- NCT06629675 — Make Every Step Count: Personalised Music Feedback to Walking for People Living With COPD · NA · recruiting
- NCT06844656 — Understanding the Increased Risk of Atrial Fibrillation in Athletes: a Case-control Study · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05853536 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Leicester
- Last refreshed: 10 May 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05853536.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing