NCT05847075

Heat Therapy and Strength Training Effects in Individuals With Type 2 Diabetes

Status unknown NA Last updated 6 May 2023

What this trial tests

NA trial testing Heat Therapy in Type 2 Diabetes in 66 participants. Status unknown.

Timeline

1 July 2023

Primary endpoint
15 January 2025

15 January 2026

Quick facts

Lead sponsor	Federal University of Rio Grande do Sul
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	66
Start date	1 July 2023
Primary completion	15 January 2025
Estimated completion	15 January 2026
Sites	2 locations across Brazil

Drugs / interventions tested

• Heat Therapy
• StrengthTraining
• Sedentary Control

Conditions studied

• Type 2 Diabetes — all drugs for Type 2 Diabetes →

Sponsor

Federal University of Rio Grande do Sul

Who can join

Adults 18 to 65, any sex, with Type 2 Diabetes. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of this study is to compare different non-pharmacological interventions in Type 2 diabetic people, testing their efficiency to improve metabolism and inflammation. The investigators will compare the effects of Heat Therapy (HT) and Strength training (ST), for 12 weeks, to test which one is more effective to improve participants health. Heat Therapy consists in submitting a person to an environmental chamber, initially set at 55 degrees Celsius on three non-consecutive days of the week. Each session will last 60 min. ST consists in supervised exercise in a gym on three non-consecutive days of the week. Each session will last \~60 min and will consist of a warm up, the resistance training and a cool down. All sessions will be conducted by qualified sport and exercise scientists for 12 weeks. A third group of people will stay sedentary without any other intervention for 12 weeks. Before, and after the end of the intervention blood samples will be collected to analyze metabolic parameters as well as inflammatory markers. The investigators hypothesize that ST and HT will reduce HbA1c levels, improve metabolic and inflammatory profile, dysbiosis, and the anti-inflammatory heat shock response (HSR).

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Effect of heat therapy compared with strength training on metabolic profile, heat shock response, inflammation, cardiovascular responses and microbiota in individuals with type 2 diabetes: study protocol of a randomized trial.
   Bock PM, Kowalewski LS, Ayres LR, Russo MKB, et al · · 2025 · PMID 40465937 · DOI 10.1590/1516-3180-2024.0040.r1.13082024
2. Effect of heat therapy compared with strength training on metabolic profile, heat shock response, inflammation, cardiovascular responses and microbiota in individuals with type 2 diabetes: Study protocol of a randomized trial
   Bock PM, Kowalewski LS, Ayres LR, Russo MKB, et al · · 2023 · DOI 10.21203/rs.3.rs-3026571/v1