Last reviewed · How we verify
NCT05846841
Personalized Tobacco Treatment in Primary Care (MOTIVATE)
NA trial testing Precision Treatment in Physician's Role in 850 participants. Currently enrolling.
31 March 2028
Quick facts
| Lead sponsor | Washington University School of Medicine |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 850 |
| Start date | 29 September 2023 |
| Primary completion | 31 March 2028 |
| Estimated completion | 30 September 2028 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Precision Treatment
- Usual Care
Conditions studied
- Physician's Role — all drugs for Physician's Role →
- Smoking Cessation — all drugs for Smoking Cessation →
- Smoking — all drugs for Smoking →
Sponsor
Washington University School of Medicine
Who can join
18 and older, any sex, with Physician's Role or Smoking Cessation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study examines the application of precision treatment intervention for smoking cessation from both the clinician perspective and patient perspective, and compares it to usual care on tobacco treatment in the primary care setting. The precision treatment intervention includes personalized tobacco treatment recommendations using the patient's clinical, genetic, and biomarker information. This approach may increase effectiveness and adherence for the patient, and increase the clinician's likelihood of prescribing.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Genomic insights for personalised care in lung cancer and smoking cessation: motivating at-risk individuals toward evidence-based health practices.
Chen T, Pham G, Fox L, Adler N, et al · · 2024 · cited 10× · PMID 39520911 · DOI 10.1016/j.ebiom.2024.105441
Verify or expand the search:
- PubMed search for NCT05846841
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Physician's Role
Currently open trials in the same condition.
- NCT07166120 — Precision Treatment to Promote Smoking Cessation and Survival in Oncology Patients · NA · recruiting
Other Washington University School of Medicine trials
Trials by the same sponsor.
- NCT05521997 — Glutaminase Inhibition and Chemoradiation in Advanced Cervical Cancer · Phase 2 · not yet recruiting
- NCT07101666 — Total Neoadjuvant Therapy With Short Course Radiation Therapy in Gastric Cancer · Phase 2 · not yet recruiting
- NCT07200089 — Recombinant Human IL-7 (NT-I7) in Relapsed/Refractory Multiple Myeloma Following BCMA CAR-T Therapy (Cilta-cel) · Phase 1 · not yet recruiting
- NCT07313592 — Whole Genome Sequencing (ChromoSeq®) for Acute Lymphoblastic Leukemia (ALL) Patients · not yet recruiting
- NCT07419464 — 5-Fluorouracil Response and Optimization STudy (The FROST Trial) · Phase 2 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05846841 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Washington University School of Medicine
- Last refreshed: 9 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05846841.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing