NCT05844579: LIBERATION

The ICU LIBERATION Study

Recruiting now Last updated 19 September 2024

What this trial tests

trial in Acute Respiratory Distress Syndrome in 1,000 participants. Currently enrolling.

Timeline

1 June 2023

Primary endpoint
31 December 2026

31 December 2031

Quick facts

Lead sponsor	Japanese Society for Early Mobilization
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	1,000
Start date	1 June 2023
Primary completion	31 December 2026
Estimated completion	31 December 2031
Sites	1 location across Japan

Conditions studied

• Acute Respiratory Distress Syndrome — all drugs for Acute Respiratory Distress Syndrome →
• Post Intensive Care Syndrome — all drugs for Post Intensive Care Syndrome →
• Treatment Compliance — all drugs for Treatment Compliance →
• Quality of Life — all drugs for Quality of Life →

Sponsor

Japanese Society for Early Mobilization

Who can join

16 and older, any sex, with Acute Respiratory Distress Syndrome or Post Intensive Care Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Acute respiratory distress syndrome (ARDS) is a condition associated with hypoxemia due to noncardiogenic causes and results in high mortality. However, the epidemiology and treatment strategy for ARDS may have changed significantly due to the accumulation of a large body of knowledge, following the two-year pandemic of the novel coronavirus (SARS-CoV-2) of which the primary manifestation is ARDS. To improve the quality of ICU care that patients receive after admission to the ICU, a variety of academic societies, including the Japanese Society of Intensive Care Medicine and the Society of Critical Care Medicine, are currently developing evidence-based guidelines and consensus guidelines and statements regarding ABCDEF bundles, nutritional therapy, ICU diary. The ABCDEF bundle, nutritional therapy, and ICU diary have been developed and are being promoted for implementation in hospitals around the world. The implementation of evidence-based ICU care is strongly recommended, especially for patients with acute respiratory distress syndrome who frequently require ventilators to maintain their lives, because their patient outcomes are worse than those who were admitted to ICU with other causes.

However, there is still little evidence on how the quality of ICU care (compliance rate) correlates with patient prognosis and outcomes, and there are currently no clear goals or indicators for the ICU care we should develop.

This study aims to investigate the epidemiology and treatments given to the patients and evaluate the implementation of evidence-based ICU care and its association with the outcomes of patients with acute respiratory distress syndrome admitted to the ICU. The contents of mechanical ventilation settings, respiratory conditions, and the evidence-based ICU care, such as analgesia, sedation, rehabilitation, and nutrition, given to the patients will be collected in a daily basis.

Aim 1: Epidemiology Aim 2: Treatments Aim 3: Evidence-based ICU care Aim 4: ARDS related Post Intensive Care Syndrome

Publications & conference data

No peer-reviewed publications indexed yet for this trial.