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NCT05843812: MgSObs
Magnesium Sulfate in Bariatric Surgery
trial testing Magnesium Sulfate 10 MG/ML in Anesthesia and Analgesia in 104 participants. Status unknown.
31 December 2023
Quick facts
| Lead sponsor | Instituto Mexicano del Seguro Social |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 104 |
| Start date | 21 April 2023 |
| Primary completion | 31 December 2023 |
| Estimated completion | 30 June 2024 |
| Sites | 1 location across Mexico |
Drugs / interventions tested
- Magnesium Sulfate 10 MG/ML — full drug profile →
Conditions studied
- Anesthesia and Analgesia — all drugs for Anesthesia and Analgesia →
- Magnesium Sulfate — all drugs for Magnesium Sulfate →
- Bariatric Surgery Candidate — all drugs for Bariatric Surgery Candidate →
Sponsor
Instituto Mexicano del Seguro Social — full company profile →
Who can join
Adults 18 to 60, any sex, with Anesthesia and Analgesia or Magnesium Sulfate. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Weight loss surgery, also known as bariatric surgery, has been around since the 1950s and since its inception has been shown to successfully achieve significant and sustainable weight loss in a large number of patients who undergo this intervention, as well , if a beneficial impact is observed in the management of metabolic disorders, such as type 2 diabetes mellitus and hyperlipidemia. After bariatric surgery, patients are at risk of narcotic-related side effects.(2) Because of this, pain management strategies must be implemented to reduce the consumption of narcotic medications. Some studies have reported that a multimodal analgesic regimen can reduce the consumption of postoperative narcotics, as well as the therapy requirements to control postoperative nausea and vomiting. It has also been reported that excess body mass is associated with changes in mineral levels in the body, particularly hypomagnesemia , a condition that is also common in hospitalized patients (Hansen \& Bruserud 2018), and has a high incidence in the perioperative environment. Magnesium sulfate (MgSO4) has multiple desirable effects in an anesthetic procedure. It is an antagonist of the N-methyl-d-aspartic acid (NMDA) receptor, which is why it produces an analgesic effect related to the prevention of central sensitization caused by peripheral tissue injury. In addition, other relevant clinical effects of MgSO4 have been reported in anesthesiology, such as its effect as a CNS depressant, modulation of the hemodynamic response, reduction of the intraoperative requirements of anesthetics, analgesics, and muscle relaxants. As well as the potentiation of the effect of non-depolarizing muscle relaxants. The role of magnesium in the body and its pharmacological properties continue to be studied and knowledge of its pharmacological, clinical and physiological characteristics has become essential for the anesthesiologist. There are no previous studies that allow establishing an optimal therapeutic scheme considering all the perioperative clinical effects of MgSO4 and that evaluate the role of genetic variability in pain perception and response to treatment in bariatric surgery.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05843812
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05843812 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Instituto Mexicano del Seguro Social
- Last refreshed: 6 May 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05843812.
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