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NCT05842759
Avoiding Postinduction Hypotension: the Clinical ZERO-HYPOTENSION Proof-of-concept Study
NA trial testing Monitoring in Hypotension in 120 participants. Completed in 7 August 2023.
7 August 2023
Quick facts
| Lead sponsor | Universitätsklinikum Hamburg-Eppendorf |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 120 |
| Start date | 7 March 2023 |
| Primary completion | 7 August 2023 |
| Estimated completion | 7 August 2023 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Monitoring
- Norepinephrine preparation
- Propofol administration — full drug profile →
- Alarm adjustment
- Intervention threshold
Conditions studied
- Hypotension — all drugs for Hypotension →
- Anesthesia — all drugs for Anesthesia →
- Hypotension on Induction — all drugs for Hypotension on Induction →
Sponsor
Universitätsklinikum Hamburg-Eppendorf — full company profile →
Who can join
Adults 45 to 130, any sex, with Hypotension or Anesthesia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this clinical proof-of-concept study, the aim is to investigate the efficacy of a hypotension avoidance strategy to prevent post-induction hypotension. Specifically, it will be investigate how much postinduction hypotension occurs when using a hypotension avoidance strategy - combining continuous intraarterial blood pressure monitoring, careful administration of anesthetic drugs, and continuous administration of norepinephrine to treat hypotension - in high-risk patients having elective non-cardiac surgery.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A bundle to prevent postinduction hypotension in high-risk noncardiac surgery patients: the ZERO-HYPOTENSION single-arm interventional proof-of-concept study.
Thomsen KK, Kröker A, Krause L, Kouz K, et al · · 2025 · cited 6× · PMID 40276620 · DOI 10.1016/j.bjao.2025.100392
Verify or expand the search:
- PubMed search for NCT05842759
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05842759 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universitätsklinikum Hamburg-Eppendorf
- Last refreshed: 11 September 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05842759.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing