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NCT05842473: RECONNECT
Long-term Effect of TMS in Primary Progressive Aphasia
NA trial testing Transcranial Magnetic Stimulation (active) in Primary Progressive Aphasia in 63 participants. Completed in 31 July 2024.
31 July 2024
Quick facts
| Lead sponsor | Hospital San Carlos, Madrid |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 63 |
| Start date | 1 February 2023 |
| Primary completion | 31 July 2024 |
| Estimated completion | 31 July 2024 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Transcranial Magnetic Stimulation (active)
- Language therapy
- Transcranial Magnetic Stimulation (sham)
Conditions studied
- Primary Progressive Aphasia — all drugs for Primary Progressive Aphasia →
- Frontotemporal Dementia — all drugs for Frontotemporal Dementia →
- Alzheimer Disease — all drugs for Alzheimer Disease →
Sponsor
Hospital San Carlos, Madrid
Who can join
18 and older, any sex, with Primary Progressive Aphasia or Frontotemporal Dementia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
There are very few treatments for neurodegenerative disorders, and the efficacy of these treatments is generally modest. Recent studies have shown a short-term positive effect of non-invasive neuromodulation techniques such as transcranial magnetic stimulation (TMS) in primary progressive aphasia (PPA). PPA is a clinical syndrome associated with Alzheimer's disease and Frontotemporal degeneration. The aim of this study is to compare the effect of TMS and language therapy versus language therapy and sham TMS in patients with PPA during 6 months. A prospective, randomized, controlled, double-blind and parallel clinical trial will be conducted. The changes in brain metabolism using FDG-PET, language, neuropsychiatric symptoms, and daily-living activities will be assessed. Connectivity changes using electroencephalography will also be examined. In addition, a subgroup of patients will be assessed with multimodal MRI (structural and functional), and blood biomarkers. As a result of this project, valuable information about the long-term efficacy of non-invasive brain stimulation in PPA will be obtained, as well as the mechanisms of the therapy and clinical and neuroimaging factors associated with therapy response.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Long-Term Therapy With Transcranial Magnetic Stimulation in Primary Progressive Aphasia: A Randomized Clinical Trial.
Fernández-Romero L, Cabrera-Martin MN, Delgado-Alonso C, Suárez-Coalla P, et al · · 2025 · cited 2× · PMID 40788648 · DOI 10.1001/jamanetworkopen.2025.26129
Verify or expand the search:
- PubMed search for NCT05842473
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Primary Progressive Aphasia
Currently open trials in the same condition.
- NCT06191198 — Communication Bridge 3 Study · Phase 2 · recruiting
- NCT06211374 — Communication Bridge Pilot Study · NA · active not recruiting
- NCT05386394 — Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia · Phase 2 · recruiting
- NCT05741853 — Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia · NA · recruiting
- NCT05443633 — Enhancing Language Function in Aphasia · NA · recruiting
Other Hospital San Carlos, Madrid trials
Trials by the same sponsor.
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- NCT06156059 — Oral Bedtime Melatonin in Critically Ill Patients · Phase 4 · unknown
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05842473 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital San Carlos, Madrid
- Last refreshed: 18 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05842473.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing