NCT05837143 (MERCURY-DCM) is a EARLY_PHASE1 clinical trial of JV001 in Heart Failure, sponsored by Shanghai East Hospital.

Who is sponsoring NCT05837143?

NCT05837143 is sponsored by Shanghai East Hospital.

What drugs are being tested in NCT05837143?

Interventions in NCT05837143: JV001.

What condition does NCT05837143 study?

NCT05837143 studies Heart Failure, Dilated Cardiomyopathy.

Is NCT05837143 still recruiting?

NCT05837143 is currently active, enrolled. Last updated 16 July 2024.

Last reviewed 2024-07-16 · How we verify

NCT05837143: MERCURY-DCM

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Myocardial Telomere Recapping Study for Dilated Cardiomyopathy

Active, enrolled EARLY_PHASE1 Last updated 16 July 2024

What this trial tests

EARLY_PHASE1 trial testing JV001 in Heart Failure in 12 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

30 March 2023

Primary endpoint
30 July 2025

30 December 2025

Quick facts

Lead sponsor	Shanghai East Hospital
Phase	EARLY_PHASE1
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	na
Design	sequential
Masking	none
Primary purpose	treatment
Enrollment	12
Start date	30 March 2023
Primary completion	30 July 2025
Estimated completion	30 December 2025
Sites	1 location across China

Drugs / interventions tested

JV001 — full drug profile →

Conditions studied

Heart Failure — all drugs for Heart Failure →
Dilated Cardiomyopathy — all drugs for Dilated Cardiomyopathy →

Sponsor

Shanghai East Hospital

Who can join

Adults 18 to 75, any sex, with Heart Failure or Dilated Cardiomyopathy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of this study is to determine the safety and feasibility of giving an adeno-associated viral vector expressing a modified telomerase protein (TERT), driven by cardiac troponin T promoter (AAV9-cTnT-modTERT), to 12 dilated cardiomyopathic patients.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Aging in Heart Failure: Embracing Biology Over Chronology: JACC Family Series.
Goyal P, Maurer MS, Roh J. · · 2024 · cited 27× · PMID 38597865 · DOI 10.1016/j.jchf.2024.02.021
Current developments of gene therapy in human diseases.
Liu F, Li R, Zhu Z, Yang Y, et al · · 2024 · cited 17× · PMID 39156766 · DOI 10.1002/mco2.645

Verify or expand the search:

Other recruiting trials for Heart Failure

Currently open trials in the same condition.

NCT06118983 — Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF) · NA · recruiting
NCT07496372 — Efficacy and Safety of Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Injection (HiCM-188) in Advanced Heart · Phase 3 · recruiting
NCT07527156 — Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure · Phase 4 · recruiting
NCT07263035 — Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure · Phase 4 · recruiting
NCT07531966 — Vascular Complications After Kidney Transplantation · recruiting

Other Shanghai East Hospital trials

Trials by the same sponsor.

NCT07519161 — Pharmacological Intervention to Prevent NOAF After TAVR · NA · not yet recruiting
NCT07516223 — MRI-Assisted Guidance for Non-Essential Tissue Sampling · NA · not yet recruiting
NCT07279259 — Thrombolysis in Early Acute Ischemic Stroke Trial-Blood Pressure Management · Phase 2 · recruiting
NCT07294495 — Effect of Henagliflozin on Myocardial Fibrosis in Non-Obstructive HCM: A Randomized, Double-Blind, Placebo-Controlled Tr · NA · not yet recruiting
NCT07290816 — Effect of Non-invasive Neuromodulation on the Quality of Intestinal Cleansing · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05837143 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Shanghai East Hospital
Last refreshed: 16 July 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05837143.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing