NCT05834517 is a Phase 4 clinical trial of Hyaluronic acid in Periodontitis, sponsored by Ehab Haider Hassan El-emam.

Who is sponsoring NCT05834517?

NCT05834517 is sponsored by Ehab Haider Hassan El-emam.

What drugs are being tested in NCT05834517?

Interventions in NCT05834517: Hyaluronic acid, non surgical periodontal therapy.

What condition does NCT05834517 study?

NCT05834517 studies Periodontitis.

Is NCT05834517 still recruiting?

NCT05834517 is currently completed. Last updated 28 April 2023.

Last reviewed 2023-04-28 · How we verify

NCT05834517

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

''Efficacy of Locally Delivered Hyaluronic Acid Gel as an Adjunctive to Non-Surgical Management of Periodontitis

Completed Phase 4 Last updated 28 April 2023

What this trial tests

Phase 4 trial testing Hyaluronic acid in Periodontitis in 28 participants. Completed in 10 December 2022.

Timeline

2 May 2022

Primary endpoint
5 December 2022

10 December 2022

Quick facts

Lead sponsor	Ehab Haider Hassan El-emam
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	28
Start date	2 May 2022
Primary completion	5 December 2022
Estimated completion	10 December 2022
Sites	1 location across Egypt

Drugs / interventions tested

Hyaluronic acid (HYALURONIC ACID) — full drug profile →
non surgical periodontal therapy

Conditions studied

Periodontitis — all drugs for Periodontitis →

Sponsor

Ehab Haider Hassan El-emam

Who can join

Adults 25 to 55, any sex, with Periodontitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Hyaluronic Acid (HA) is an addition to the local chemotherapeutic agents. Hyaluronic acid was discovered by Meyer and Palmer. HA is widely found in the extracellular matrix and it plays an essential role in controlling cell behavior including random motility, metabolic reactions, chemotaxis, proliferation and invasion. HA is released by many cells including fibroblasts (Dahiya et al., 2013). Hyaluronic acid can be found in the skin, eyes and the periodontium. In addition, it appears in body fluids like serum, gingival crevicular fluid and saliva. Hyaluronic acid is created in the periodontium by HA synthase enzyme present in numerous cells like fibroblast and cementoblast (Fraser et al., 1997). There is evidence that hyaluronic acid is bacteriostatic, fungostatic, anti-inflammatory, osteoconduvtive and pro-angiogenic. These dissimilar properties illustrate the ability of hyaluronic acid to be an ideal material for wound healing (Carlson et al., 2004).

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of Hyaluronic acid

Trials testing the same drug.

NCT07236632 — Hyaluronic Acid vs Botulinum Toxin Injection in Treatment of Lifelong Drug-Resistant Premature Ejaculation: Randomized S · NA · not yet recruiting
NCT06437054 — Verification of the Efficacy/Safety of the Mixed Drug Injectable Delivery Vehicle for Treating Intractable Hearing Loss · Phase 1, PHASE2 · not yet recruiting
NCT07437885 — Effects of the Adjunctive Use of Hyaluronic Acid-based Gel With Coranally Advanced Flap in the Gingival Recession · Phase 1, PHASE2 · completed
NCT06253975 — Randomized, Controlled, Multicenter Study of Extracellular Vesicles From Human Adipose Tissue Promoting Wound Healing · NA · unknown
NCT06694532 — EffIcacy Between Arthrocentesis With High Versus Low Molecular Weight Hyaluronic Acid in Treatment of TMJ Disorders · Phase 1, PHASE2 · recruiting

Other recruiting trials for Periodontitis

Currently open trials in the same condition.

NCT07463859 — Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabet · NA · recruiting
NCT07535177 — Gas6 and Soluble MerTK in Periodontal Diseases · recruiting
NCT07491848 — Oral-Periodontal Evaluation and Assessment of Oral Fluid Biomarkers in Patients With Hepatitis B+D · recruiting
NCT07421960 — Investigation of the Relationship Between Periodontitis and Sleep Quality · recruiting
NCT07532694 — Diode Laser-Assisted Periodontal Therapy in Kidney Transplant Recipients · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05834517 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ehab Haider Hassan El-emam
Last refreshed: 28 April 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05834517.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing