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NCT05828446: AMRIK

Improving Hepatocellular Carcinoma Screening

Recruiting now NA Last updated 3 April 2025
What this trial tests

NA trial testing MRI in Magnetic Resonance Imaging in 330 participants. Currently enrolling.

Timeline
1 April 2023
Primary endpoint
30 April 2026
30 April 2027

Quick facts

Lead sponsorNaik Vietti Violi
PhaseNA
StatusRecruiting now
Study typeINTERVENTIONAL
Allocationna
Designsingle group
Maskingnone
Primary purposescreening
Enrollment330
Start date1 April 2023
Primary completion30 April 2026
Estimated completion30 April 2027
Sites1 location across Switzerland

Drugs / interventions tested

Conditions studied

Sponsor

Naik Vietti Violi

Who can join

18 and older, any sex, with Magnetic Resonance Imaging or Hepatocellular Carcinoma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a monocentric, single blind, interventional, single arm study. It is designed to compare the rates of detection of hepatocellular carcinoma (HCC) by ultrasound (US) used in clinical routine vs. abbreviated magnetic resonance imaging (AMRI). The hypothesis is that dynamic AMRI with extracellular contrast agent injection has a higher patient-level detection rate of HCC than screening US and non-contrast AMRI. Interested and eligible patients will be enrolled and undergo HCC screening rounds including US +/- contrast-enhanced US (clinical routine) and screening MRI within the same week bi-annually.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Recent advances and issues in imaging modalities for hepatocellular carcinoma surveillance.
    Lee DH. · · 2025 · cited 5× · PMID 40007309 · DOI 10.17998/jlc.2025.02.16
  2. Persisting challenges in the early detection of hepatocellular carcinoma.
    Arvind A, Redmon K, Singal AG. · · 2025 · cited 3× · PMID 39943795 · DOI 10.1080/14737140.2025.2467184
  3. Abbreviated MRI-Based Surveillance Strategies for Early Hepatocellular Carcinoma Detection.
    Park HJ, Kim DW, Choi WM, Kim SY. · · 2025 · cited 1× · PMID 40502477 · DOI 10.3348/jksr.2024.0153

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Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05828446.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing