Who is sponsoring NCT05824546?

NCT05824546 is sponsored by National Neuroscience Institute.

What drugs are being tested in NCT05824546?

Interventions in NCT05824546: Intervention Arm (uSINE-PAMS-technique).

What condition does NCT05824546 study?

NCT05824546 studies Ultrasound Therapy, Lumbar Puncture.

Is NCT05824546 still recruiting?

NCT05824546 is currently recruiting now. Last updated 16 May 2024.

Last reviewed 2024-05-16 · How we verify

NCT05824546

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

uSINE-PAMS Artificial Intelligence Driven, Ultrasound-Guided Lumbar Puncture to Improve Procedural Accuracy

Recruiting now NA Last updated 16 May 2024

What this trial tests

NA trial testing Intervention Arm (uSINE-PAMS-technique) in Ultrasound Therapy in 50 participants. Currently enrolling.

Timeline

26 May 2023

Primary endpoint
31 July 2024

31 July 2024

Quick facts

Lead sponsor	National Neuroscience Institute
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	diagnostic
Enrollment	50
Start date	26 May 2023
Primary completion	31 July 2024
Estimated completion	31 July 2024
Sites	1 location across Singapore

Drugs / interventions tested

Intervention Arm (uSINE-PAMS-technique)

Conditions studied

Ultrasound Therapy — all drugs for Ultrasound Therapy →
Lumbar Puncture — all drugs for Lumbar Puncture →

Sponsor

National Neuroscience Institute

Who can join

Adults 21 to 105, any sex, with Ultrasound Therapy or Lumbar Puncture. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to test the effectiveness of uSINE-PAMS technology for lumbar puncture compared to traditional landmark-based technique. uSINE is a machine-learning software designed to aid the operators in ultrasound-guided lumbar puncture while PAMS is a two-part hardware to translate data from ultrasound to accurate needle insertion and angulation.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

uSINE-PAMS Artificial Intelligence-Driven, Ultrasound-Guided Lumbar Puncture to Improve Procedural Accuracy: A Pilot Study Report.
Lin X, Lam MLC, Chuang DF, Yuen JYE, et al · · 2025 · PMID 40201070 · DOI 10.1212/cpj.0000000000200447

Verify or expand the search:

Other National Neuroscience Institute trials

Trials by the same sponsor.

NCT05644171 — RESTORES Trial: RESToration Of Rehabilitative Function With Epidural Spinal Stimulation · NA · recruiting
NCT03711903 — Evaluation of CN-105 in Subject With Acute Supratentorial Intracerebral Hemorrhage · Phase 2 · completed
NCT03811301 — [BrainConnexion] - Neurodevice Phase I Trial · NA · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05824546 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by National Neuroscience Institute
Last refreshed: 16 May 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05824546.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing