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NCT05822570
Oxygen Dissociation Curve in Patients Undergoing Orthotopic Liver Transplantation
trial testing Assessment of Oxygen Dissociation Curve (ODC) in Liver Transplantation in 30 participants. Completed in 31 October 2024.
30 September 2024
Quick facts
| Lead sponsor | Medical University Innsbruck |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 30 |
| Start date | 1 May 2023 |
| Primary completion | 30 September 2024 |
| Estimated completion | 31 October 2024 |
| Sites | 1 location across Austria |
Drugs / interventions tested
- Assessment of Oxygen Dissociation Curve (ODC)
Conditions studied
- Liver Transplantation — all drugs for Liver Transplantation →
Sponsor
Medical University Innsbruck
Who can join
Adults 18 to 99, any sex, with Liver Transplantation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Hemoglobin (Hb) is the molecule responsible for the transport of oxygen (O2) to the tissues in mammals. The p50 and the Hill coefficient (HC) best describe the ODC. The interaction between Hb and O2 can be influenced by many agents and conditions like temperature, pH, pCO2 and 2,3-diphosphoglycerate (2,3-DPG). During liver transplantation numerous profound physiological changes occur, linked to the different stages of the surgical procedure. Previous studies in humans and animals undergoing liver transplantation have shown that while the ODC seems preserved during preparation and the anhepatic phase, a left shift of the ODC occurs after reperfusion . This left shift of the ODC could imply a decreased release of oxygen to the tissues, probably worsening hemodynamic instability. With this pilot study the investigator aim to measure ODCs at baseline and at different stages during orthotopic liver transplantation in patients in order to get deeper understanding of oxygen delivery and supply during liver transplantation surgery.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
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- PubMed search for NCT05822570
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05822570 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Medical University Innsbruck
- Last refreshed: 26 March 2025
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