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NCT05819814: PROACT 1
Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Change in Cardiovascular Health
NA trial testing Disclosure of high polygenic risk result for coronary artery disease in Coronary Artery Disease in 200 participants. Currently enrolling.
1 May 2026
Quick facts
| Lead sponsor | Massachusetts General Hospital |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 200 |
| Start date | 7 December 2023 |
| Primary completion | 1 May 2026 |
| Estimated completion | 1 May 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Disclosure of high polygenic risk result for coronary artery disease
Conditions studied
- Coronary Artery Disease — all drugs for Coronary Artery Disease →
Sponsor
Massachusetts General Hospital
Who can join
Adults 40 to 75, any sex, with Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this randomized controlled trial is to assess the impact of disclosing a high polygenic risk result for coronary artery disease on change in cardiovascular health over one year.
Publications & conference data
5 peer-reviewed publications reference this trial (live from Europe PMC):
-
Instability of high polygenic risk classification and mitigation by integrative scoring.
Misra A, Truong B, Urbut SM, Sui Y, et al · · 2025 · cited 16× · PMID 39939586 · DOI 10.1038/s41467-025-56945-0 -
Polygenic Risk Is Associated With Long-Term Coronary Plaque Progression and High-Risk Plaque.
Nurmohamed NS, Shim I, Gaillard EL, Ibrahim S, et al · · 2024 · cited 10× · PMID 39152960 · DOI 10.1016/j.jcmg.2024.06.015 -
Polygenic Risk Based Detection and Treatment of Subclinical Coronary Atherosclerosis in the PROACT Clinical Trials.
Abou-Karam R, Kim MS, Jemma Cho SM, Bitar F, et al · · 2026 · cited 1× · PMID 41706060 · DOI 10.1016/j.jacc.2025.12.032 -
Breaking binary in cardiovascular disease risk prediction.
Zhang Y, Fahed AC. · · 2025 · PMID 41776352 · DOI 10.1038/s44325-024-00041-7 -
Unraveling the genetic blueprint of coronary artery disease: The role of polygenic risk scores in risk prediction.
El Ghazawi A, Fahed AC, Fawaz N, Fakih Y, et al · · 2026 · PMID 41561400 · DOI 10.1016/j.ahjo.2025.100712
Verify or expand the search:
- PubMed search for NCT05819814
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Massachusetts General Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05819814 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Massachusetts General Hospital
- Last refreshed: 23 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05819814.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing