Last reviewed · How we verify
NCT05818475: AIR-STEMI
Functional Coronary Angiography Guided Revascularization in STEMI
NA trial testing Angiography-guided PCI in Myocardial Infarction in 1,823 participants. Participants enrolled and being followed up; not accepting new ones.
31 January 2026
Quick facts
| Lead sponsor | University Hospital of Ferrara |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 1,823 |
| Start date | 8 May 2023 |
| Primary completion | 31 January 2026 |
| Estimated completion | 31 January 2028 |
| Sites | 22 locations across Pakistan, Italy |
Drugs / interventions tested
- Angiography-guided PCI
- Angiography-derived FFR PCI indication and planning
Conditions studied
- Myocardial Infarction — all drugs for Myocardial Infarction →
Sponsor
University Hospital of Ferrara
Who can join
18 and older, any sex, with Myocardial Infarction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this multicenter randomized clinical trial is to test the superiority in terms of efficacy of the Angiography-derived fractional flow reserve (AIR) over that based on conventional angiography (ANGIO) strategy in the management of non-culprit lesions in STEMI patients with multivessel disease. The main questions it aims to answer are: * is an Angiography-derived fractional flow reserve strategy superior to a conventional angiography strategy in reducing the occurrence of the composite efficacy endpoint of all-cause death, myocardial infarction, cerebrovascular accident, or ischemia-driven revascularization. * is an Angiography-derived fractional flow reserve strategy superior to a conventional angiography strategy in reducing the occurrence of the composite safety endpoint of of contrast-associated acute kidney injury and Bleeding Academic Research Consortium (BARC) type 3-5. Participants will be randomized after the successful treatment of the culprit lesion to one of the two strategies and prospectively followed-up.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Functional coronary angiography to indicate and guide revascularization in STEMI patients with multivessel disease: Rationale and design of the AIR-STEMI trial.
Erriquez A, Colaiori I, Hakeem A, Guiducci V, et al · · 2025 · cited 2× · PMID 39984150 · DOI 10.1016/j.ahj.2025.02.012
Verify or expand the search:
- PubMed search for NCT05818475
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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- NCT04063345 — Long-term Clinical Outcomes of intraVascular Ultrasound-guided vs Angiography-guided Primary pErcutaneous Intervention i · Phase 2, PHASE3 · unknown
Other recruiting trials for Myocardial Infarction
Currently open trials in the same condition.
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Other University Hospital of Ferrara trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05818475 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital of Ferrara
- Last refreshed: 4 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05818475.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing