NCT05816512: GNPG

Antimicrobial Efficacy of Biogenic Gold Nano Particle From Pelargonium Graveolens Leaves Extract Mouthwash for Children

Status unknown NA Last updated 18 April 2023

What this trial tests

NA trial testing Gold Nano particle from Pelargonium Graveolens Mouthwash in Dental Caries in 60 participants. Status unknown.

Timeline

1 April 2023

Primary endpoint
20 September 2023

20 March 2024

Quick facts

Lead sponsor	Ahmed Yousif Mahdi
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	60
Start date	1 April 2023
Primary completion	20 September 2023
Estimated completion	20 March 2024
Sites	1 location across Iraq

Drugs / interventions tested

• Gold Nano particle from Pelargonium Graveolens Mouthwash — full drug profile →
• Chlorhexidine gluconate mouthwash . — full drug profile →

Conditions studied

• Dental Caries — all drugs for Dental Caries →
• Gingivitis — all drugs for Gingivitis →
• Periodontitis — all drugs for Periodontitis →

Sponsor

Ahmed Yousif Mahdi — full company profile →

Who can join

Adults 7 to 14, male only, with Dental Caries or Gingivitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The study is randomized controlled trial ... The null hypothesis of the present study is that there is no antibacterial efficacy of gold nanoparticles of pelargonium graveolens mouthwash against Streptococcus mutans and Candida Albicans . Meanwhile the alternative hypothesis of the present study is that gold nanoparticles of pelargonium graveolens mouthwash have antimicrobial activity against Streptococcus mutans and Candida Albicans .

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

1. Gold nanostructures in melanoma: Advances in treatment, diagnosis, and theranostic applications.
   Dastgheib ZS, Abolmaali SS, Farahavar G, Salmanpour M, et al · · 2024 · cited 14× · PMID 39170173 · DOI 10.1016/j.heliyon.2024.e35655
2. Harnessing Nature's Toolbox: Naturally Derived Bioactive Compounds in Nanotechnology Enhanced Formulations.
   Sanjai C, Gaonkar SL, Hakkimane SS. · · 2024 · cited 10× · PMID 39494011 · DOI 10.1021/acsomega.4c07756
3. Medical importance and pharmacokinetics of gold nanoparticles in the human body.
   Singh P, Joshi AS, Singh H, Mijakovic I. · · 2025 · cited 8× · PMID 41068777 · DOI 10.1186/s12943-025-02418-3
4. Phytonanotherapy for the Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease.
   Nendouvhada LP, Sibuyi NRS, Fadaka AO, Meyer S, et al · · 2024 · cited 5× · PMID 38891759 · DOI 10.3390/ijms25115571
5. Antimicrobial Efficacy of Pelargonium Graveolens Gold Nanoparticles: A Novel Mouthwash for Children.
   Asker AYM, Al Haidar AHMJ. · · 2026 · PMID 42036760 · DOI 10.1111/idh.70071