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NCT05816317
Randomized Controlled Trial of a Single-session Mechanism-focused Intervention for Suicidal Thoughts and Behaviors
NA trial testing Single-Session Mechanism-Focused Intervention (SSMFI) in Suicidal Ideation in 38 participants. Completed in 20 May 2025.
20 May 2025
Quick facts
| Lead sponsor | Shannon E. Sauer-Zavala |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 38 |
| Start date | 16 October 2024 |
| Primary completion | 20 May 2025 |
| Estimated completion | 20 May 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Single-Session Mechanism-Focused Intervention (SSMFI)
- Distress Tolerance Skills Review
Conditions studied
- Suicidal Ideation — all drugs for Suicidal Ideation →
- Hopelessness — all drugs for Hopelessness →
- Wish to Live — all drugs for Wish to Live →
- Wish to Die — all drugs for Wish to Die →
Sponsor
Shannon E. Sauer-Zavala
Who can join
18 and older, any sex, with Suicidal Ideation or Hopelessness. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Across multiple models of suicide risk, hopelessness and perceptions of social relatedness (i.e., lack of social connection/thwarted belongingness, perceived burdensomeness) have emerged as candidate mechanisms that maintain STBs. Although these mechanisms have garnered strong empirical support in predicting STBs, there has been virtually no integration with interventions aimed for individuals at acute risk for suicide. Thus, the overarching goal of the present proposal is to evaluate a mechanism-focused intervention that explicitly targets two core mechanisms implicated in the maintenance of STBs: hopelessness and negative perceptions of social relatedness. Given that the period immediately following hospital discharge presents the highest risk for suicide attempts and up to 70% of patients admitted for a suicide attempt do not attend their first outpatient appointment, the intervention will be evaluated on an inpatient unit. Additionally, most of the extant interventions for STBs are administered across multiple sessions (i.e., 4 sessions and up to one year); however treatments of this length are unlikely to be feasible in acute care settings. Fortunately, very brief suicide prevention interventions, are effective in reducing future suicide attempts and increasing the likelihood of attending follow-up treatments. Additionally, single-session interventions (not suicide specific) have been shown to reduce hopelessness immediately and at a one-month follow-up. The present study is an RCT comparing a novel Single Session Mechanism Focused Intervention (SSMFI) for STBs to treatment-as-usual (TAU) on a psychiatric inpatient unit for patients admitted for suicidal ideation or attempt. The engagement of the putative processes (hopelessness and negative perceptions of social relatedness) that maintain STBs will be assessed, along with the feasibility and acceptability of SSMFI for STBs on an inpatient psychiatric unit.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05816317
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Suicidal Ideation
Currently open trials in the same condition.
- NCT07438912 — Mind After Midnight · NA · recruiting
- NCT07238192 — Augmenting Massed Cognitive Processing Therapy (CPT) to Prevent Suicide Risk Among Patients With PTSD · NA · recruiting
- NCT07217444 — Improving Outcomes in Adolescent Inpatient Depression With Deep Transcranial Magnetic Stimulation · NA · recruiting
- NCT07259408 — Co-creation of Tools for People in Detention With Suicidal Thoughts and/or Behavior · recruiting
- NCT07305701 — Cohort Study on Medical Students' Mental Health · recruiting
Other Shannon E. Sauer-Zavala trials
Trials by the same sponsor.
- NCT06005129 — Personality Change Study for Borderline Personality Disorder · NA · active not recruiting
- NCT04642898 — Increasing Treatment Efficacy Using SMART Methods for Personalizing Care · NA · completed
- NCT04587518 — Five Factor Model Treatment for Borderline Personality Disorder · NA · completed
- NCT04584879 — Transdiagnostic Treatment Personalization · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05816317 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Shannon E. Sauer-Zavala
- Last refreshed: 1 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05816317.
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