NCT05814744

Efficacy of Adding Dexmedetomidine in Ultrasound-guided Intermediate Cervical Plexus Block for Thyroidectomy Surgery

Completed NA Last updated 5 April 2024

What this trial tests

NA trial testing dexmedetomidine in Pain, Postoperative in 60 participants. Completed in 1 November 2023.

Timeline

1 April 2023

Primary endpoint
1 October 2023

1 November 2023

Quick facts

Lead sponsor	National Cancer Institute, Egypt
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	60
Start date	1 April 2023
Primary completion	1 October 2023
Estimated completion	1 November 2023
Sites	1 location across Egypt

Drugs / interventions tested

• dexmedetomidine (dexmedetomidine) — full drug profile →
• bupivacaine 0.25% — full drug profile →
• Thyroidectomy Surgery
• Ultrasound-guided intermediate Cervical Plexus Block Technique

Conditions studied

• Pain, Postoperative — all drugs for Pain, Postoperative →
• Cancer of Larynx — all drugs for Cancer of Larynx →

Sponsor

National Cancer Institute, Egypt

Who can join

Adults 18 to 60, any sex, with Pain, Postoperative or Cancer of Larynx. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The cervical plexus block (CPB) is one such block used to provide effective anesthesia and analgesia for surgery in the head and neck region. The cervical fascia was first described as a very strong and resisting structure, consisting of two layers, superficial and deep. But more recently classified the cervical fascia as superficial/subcutaneous and deep. The deep cervical fascia is further divided into three layers: (a) the superficial layer, which was also called the investing fascia but is now referred to as the masticator fascia, submandibular fascia or sternocleidomastoid (SCM)-trapezius fascia, (b) the middle layer, which is suggested as to be named as strap muscle fascia or visceral fascia; and (c) the deep layer or the 'prevertebral fascia'. Intermediate cervical plexus block (CPB) has been found to be very effective in procedures of neck such as thyroid surgeries and carotid endarterectomy. The duration of analgesia following the nerve blocks is a matter of concern as most of the blocks last for only a few hours. Interestingly, resurgence of the use of α2-agonists in combination with local anesthetics has dramatically improved the duration of action of these blocks. Dexmedetomidine is a potent α2 agonist and is now emerging as an adjuvant to regional anesthesia and analgesia. Little evidence is available supporting the usefulness of dexmedetomidine in bilateral intermediate CPB. Therefore, the current study will be conducted to compare the duration and effectiveness of post-thyroidectomy analgesia of bilateral intermediate CPB using 20 ml bupivacaine 0.25% (Group A) or 20 ml of bupivacaine 0.25% with 1 μg/kg dexmedetomidine (Group B).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Efficacy of adding dexmedetomidine as adjuvant with bupivacaine in ultrasound-guided intermediate cervical plexus block for thyroidectomy surgery: randomized controlled study.
   Mostafa MM, Gamal RM, Ahmed Baiomy AM, Hassan ME, et al · · 2025 · cited 1× · PMID 40133795 · DOI 10.1186/s12871-025-02990-7