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NCT05814705
The Effects of Protein Supplementation With or Without Urolithin A During Single-leg Immobilization
NA trial testing Protein supplement in Healthy in 24 participants. Participants enrolled and being followed up; not accepting new ones.
31 May 2024
Quick facts
| Lead sponsor | McMaster University |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | basic science |
| Enrollment | 24 |
| Start date | 1 June 2023 |
| Primary completion | 31 May 2024 |
| Estimated completion | 30 April 2025 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Protein supplement — full drug profile →
- Protein supplement with Urolithin A
Conditions studied
- Healthy — all drugs for Healthy →
- Muscle Disuse Atrophy — all drugs for Muscle Disuse Atrophy →
Sponsor
McMaster University
Who can join
Adults 18 to 30, male only, with Healthy or Muscle Disuse Atrophy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
There are times in life when people cannot use their muscles, such as during illness or injury. Muscle and mitochondria (the 'energy factory' in cells) health decline very quickly when people cannot use their muscles, but certain foods can help reduce these declines. Recent research suggests that Urolithin A, which is a natural compound that can be produced after eating pomegranates, nuts, and berries, improves muscle health. In this study, the investigators aim to investigate if a protein beverage (standard care during disuse) with or without Urolithin A can reduce or prevent the loss of muscle health while wearing a knee brace (muscle disuse).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Mitophagy Activation by Urolithin A to Target Muscle Aging.
Faitg J, D'Amico D, Rinsch C, Singh A. · · 2024 · cited 11× · PMID 37925671 · DOI 10.1007/s00223-023-01145-5
Verify or expand the search:
- PubMed search for NCT05814705
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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Other McMaster University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05814705 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by McMaster University
- Last refreshed: 2 October 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05814705.
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