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NCT05814549
A Study Using Human Papillomavirus (HPV) DNA Testing to Detect HPV-Related Oropharyngeal Cancer (OPC)
trial testing NavDx in Oropharyngeal Cancer in 9 participants. Participants enrolled and being followed up; not accepting new ones.
31 March 2031
Quick facts
| Lead sponsor | Memorial Sloan Kettering Cancer Center |
|---|---|
| Status | Active, enrolled |
| Study type | OBSERVATIONAL |
| Enrollment | 9 |
| Start date | 31 March 2023 |
| Primary completion | 31 March 2031 |
| Estimated completion | 31 March 2031 |
| Sites | 7 locations across United States |
Drugs / interventions tested
- NavDx
Conditions studied
- Oropharyngeal Cancer — all drugs for Oropharyngeal Cancer →
- HPV-Related Carcinoma — all drugs for HPV-Related Carcinoma →
- HPV Positive Oropharyngeal Squamous Cell Carcinoma — all drugs for HPV Positive Oropharyngeal Squamous Cell Carcinoma →
Sponsor
Memorial Sloan Kettering Cancer Center — full company profile →
Who can join
45 and older, any sex, with Oropharyngeal Cancer or HPV-Related Carcinoma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The researchers think that a blood test (NavDx®) may be able to identify cancer early by looking for circulating DNA from Human Papillomavirus/HPV. Circulating DNA are small pieces of genes that are released into the bloodstream. The purpose of this study is to find out whether using this blood test to test for HPV DNA will help detect HPV-related Oropharyngeal Cancer/OPC.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The Value of Circulating Tumor HPV DNA in Head and Neck Squamous Cell Cancer: A Review.
Dok R, Nuyts S, Lopez F, Bradford C, et al · · 2025 · PMID 41226001 · DOI 10.3390/diagnostics15212708
Verify or expand the search:
- PubMed search for NCT05814549
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Oropharyngeal Cancer
Currently open trials in the same condition.
- NCT07209189 — Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-esca · Phase 2 · recruiting
- NCT06446713 — PIRATES: Image-guided Hyper-fractioned Dose-escalation With Proton Therapy for Head and Neck Cancer · Phase 1 · recruiting
- NCT06747390 — Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery · Phase 1 · recruiting
- NCT05363709 — BALSTILIMAB on Viral Clearance in HPV+ Oropharyngeal Cancer Patients · Phase 2 · active not recruiting
- NCT05862792 — Liposomal Bupivacaine and Transoral Robotic Surgery · recruiting
Other Memorial Sloan Kettering Cancer Center trials
Trials by the same sponsor.
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- NCT07483307 — A Study of the Impact of Endocrine Therapy on Surgical Outcomes in People With Breast Cancer · Phase 2 · recruiting
- NCT07459673 — HERizon-Breast: A ctDNA-Guided Adaptive Study of Sequential Anti-HER2 Therapies and CNS Prophylaxis to Induce Long-Term · Phase 2 · recruiting
- NCT07449195 — A Study Comparing Two Optical Coherence Tomography Devices in People With Ocular Tumors · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05814549 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Memorial Sloan Kettering Cancer Center
- Last refreshed: 19 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05814549.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing