NCT05813379

Mesenchymal Stem Cells Derived Exosomes in Skin Rejuvenation

Status unknown Phase 1, PHASE2 Last updated 14 April 2023

What this trial tests

Phase 1, PHASE2 trial testing exosime injection in Anti Aging in 20 participants. Status unknown.

Timeline

1 February 2022

Primary endpoint
29 July 2023

30 August 2023

Quick facts

Lead sponsor	Isfahan University of Medical Sciences
Phase	Phase 1, PHASE2
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	prevention
Enrollment	20
Start date	1 February 2022
Primary completion	29 July 2023
Estimated completion	30 August 2023
Sites	1 location across Iran

Drugs / interventions tested

• exosime injection

Conditions studied

• Anti Aging — all drugs for Anti Aging →

Sponsor

Isfahan University of Medical Sciences

Who can join

Adults 35 to 65, female only, with Anti Aging. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Aging is a natural and complex process. The effect of environmental factors, genetics on the body eventually leads to damage in different ways. Exosomes are present in almost all body fluids, such as synovial fluid and blood. Exosomes and microvesicles are very efficient mediators of cell-to-cell communication by transferring their specific cargo to recipient cells; for example, exosomes are involved in the delivery of genetic materials, causing epigenetic modifications in the target cells .The applications of MSC-derived exosomes have more effect in cutaneous regeneration by collagen stimulation.The basic biology of exosomes indicates that MSC-exosomes may contain MSC-specific components to exert specific effects on recipient cells, which are somewhat equivalent to the regenerative effects of MSCs. This study aims to slow down the aging process of the skin by using exosome.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Clinical applications of stem cell-derived exosomes.
   Tan F, Li X, Wang Z, Li J, et al · · 2024 · cited 390× · PMID 38212307 · DOI 10.1038/s41392-023-01704-0
2. Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges.
   Ding JY, Chen MJ, Wu LF, Shu GF, et al · · 2023 · cited 117× · PMID 37587531 · DOI 10.1186/s40779-023-00472-w
3. Biogenesis, Isolation, and Detection of Exosomes and Their Potential in Therapeutics and Diagnostics.
   Sonbhadra S, Mehak, Pandey LM. · · 2023 · cited 51× · PMID 37622888 · DOI 10.3390/bios13080802
4. Exosomes in Precision Oncology and Beyond: From Bench to Bedside in Diagnostics and Therapeutics.
   Youssef E, Palmer D, Fletcher B, Vaughn R. · · 2025 · cited 40× · PMID 40149276 · DOI 10.3390/cancers17060940
5. Insight into the Functional Dynamics and Challenges of Exosomes in Pharmaceutical Innovation and Precision Medicine.
   Sharma A, Yadav A, Nandy A, Ghatak S. · · 2024 · cited 40× · PMID 38931833 · DOI 10.3390/pharmaceutics16060709
6. Understanding molecular characteristics of extracellular vesicles derived from different types of mesenchymal stem cells for therapeutic translation.
   Ding Z, Greenberg ZF, Serafim MF, Ali S, et al · · 2024 · cited 34× · PMID 38957857 · DOI 10.1016/j.vesic.2024.100034
7. Mesenchymal stromal/stem cell tissue source and in vitro expansion impact extracellular vesicle protein and miRNA compositions as well as angiogenic and immunomodulatory capacities.
   Liu Y, Sun L, Li Y, Holmes C. · · 2024 · cited 30× · PMID 39092563 · DOI 10.1002/jev2.12472
8. Standardized Reporting of Research on Exosomes to Ensure Rigor and Reproducibility.
   Yadav A, Xuan Y, Sen CK, Ghatak S. · · 2024 · cited 28× · PMID 38888007 · DOI 10.1089/wound.2024.0093