Last reviewed · How we verify
NCT05809271
Acute Effects of 3,4-methylenedioxymethamphetamine (MDMA) With and Without a Booster Dose
Phase 1 trial testing MDMA 120 mg + MDMA 60 mg in Healthy in 25 participants. Completed in 7 March 2025.
7 March 2025
Quick facts
| Lead sponsor | University Hospital, Basel, Switzerland |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | triple |
| Primary purpose | basic science |
| Enrollment | 25 |
| Start date | 17 November 2023 |
| Primary completion | 7 March 2025 |
| Estimated completion | 7 March 2025 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- MDMA 120 mg + MDMA 60 mg — full drug profile →
- MDMA 120 mg + placebo — full drug profile →
- Placebo
Conditions studied
- Healthy — all drugs for Healthy →
Sponsor
University Hospital, Basel, Switzerland
Who can join
Adults 18 to 65, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
3,4-methylenedioxymethamphetamine (MDMA) is a psychoactive substance and prototypical empathogen acutely inducing feelings of heightened mood, empathy, trust and closeness to others. The current study investigates differences in duration of acute effects and side effects after administration of a single dose of MDMA compared to a repeated administration.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Can research on entactogens contribute to a deeper understanding of human sexuality?
Holka-Pokorska J. · · 2023 · cited 4× · PMID 37935915 · DOI 10.1007/s43440-023-00552-7
Verify or expand the search:
- PubMed search for NCT05809271
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05809271 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Basel, Switzerland
- Last refreshed: 19 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05809271.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing