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NCT05802433

The Genetic Effects on Vitamin D Supplementation

Status unknown NA Last updated 6 April 2023
What this trial tests

NA trial testing Vitamin D3 supplement in Vitamin D Deficiency in 67 participants. Status unknown.

Timeline
16 May 2022
Primary endpoint
25 August 2023
5 October 2023

Quick facts

Lead sponsorSt. Mary's University, Twickenham
PhaseNA
StatusStatus unknown
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingsingle
Primary purposebasic science
Enrollment67
Start date16 May 2022
Primary completion25 August 2023
Estimated completion5 October 2023
Sites1 location across United Kingdom

Drugs / interventions tested

Conditions studied

Sponsor

St. Mary's University, Twickenham

Who can join

Adults 18 to 65, any sex, with Vitamin D Deficiency. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Vitamin D is essential for skeletal growth and bone health, deficiency causes rickets and osteomalacia. In the UK 29% of adults have vitamin D deficiency. It is recommended all adults take 10µg vitamin D supplement daily. Genetic variations could alter vitamin D status by affecting vitamin D metabolism. Systematic reviews found variations in VDR, GC and CYP2R1 genes are associated with vitamin D deficiency. This study aims to assess the effects between vitamin D supplementation and variations in VDR, GC and CYP2R1 genes on vitamin D status.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions.
    Jin P, Duan X, Huang Z, Dong Y, et al · · 2025 · cited 21× · PMID 40717128 · DOI 10.1038/s41392-025-02270-3

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Other recruiting trials for Vitamin D Deficiency

Currently open trials in the same condition.

Other St. Mary's University, Twickenham trials

Trials by the same sponsor.

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