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NCT05801042
Effect of Encapsulated Vs Free Probiotic on Brain Function
NA trial testing Maltodextrin in Aging in 91 participants. Completed in 30 September 2024.
10 November 2023
Quick facts
| Lead sponsor | Robert Brummer |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | other |
| Enrollment | 91 |
| Start date | 7 February 2023 |
| Primary completion | 10 November 2023 |
| Estimated completion | 30 September 2024 |
| Sites | 1 location across Sweden |
Drugs / interventions tested
- Maltodextrin (MALTODEXTRIN) — full drug profile →
- Encapsulated Lactocaseibacillus rhamnosus
- Non-encapsulated Lactocaseibacillus rhamnosus
Conditions studied
- Aging — all drugs for Aging →
Sponsor
Robert Brummer
Who can join
Adults 60 to 80, any sex, with Aging. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Aging is associated with changes in a wide variety of brain networks, including the default mode, saliency attention, and visual networks. Furthermore, current research suggests that a relationship exists between functional connectivity at rest and cognition. Lactocaseibacillus rhamnosus is an ideal strain for the intervention, as it has been show to affect the gut-brain axis, brain function, and behavior. Therefore, the investigators plan to assess resting state functional magnetic resonance imaging (fMRI) to compare changes in brain connectivity between the groups receiving the encapsulate and non-encapsulated Lactocaseibacillus rhamnosus supplements.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Micro-encapsulation differentially impacts probiotic effects on brain structure and function in an elderly population - A randomised placebo-controlled trial.
Rode J, Hutchinson AN, Chatzopoulou MS, Bleiel SB, et al · · 2025 · cited 1× · PMID 40976401 · DOI 10.1016/j.bbi.2025.106113
Verify or expand the search:
- PubMed search for NCT05801042
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Aging
Currently open trials in the same condition.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05801042 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Robert Brummer
- Last refreshed: 8 October 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05801042.
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