Maternal Characteristics Associated With Child Growth and Adiposity. Search for Nutrigenomic Biomarkers in Peripheral Blood

NCT05798676 RECRUITING

The goal of this observational study is to investigate the concentrations of leptin, insulin, liver expressed antimicrobial peptide 2 (LEAP2), and cortisol in plasma and breast milk and their relationship with eating behavior, growth, adiposity and with the levels of these hormones in infants, comparing mothers with normal weight and with pre-pregnancy overweight/obesity. The main question\[s\] it aims to answer are: * Are maternal hormones associated with child growth and adiposity * Are maternal hormone receptors associated with child growth and adiposity * Are infant hormones and their receptors associated with child growth and adiposity * Are maternal and infant hormones and their receptors associated with child eating behavior Participants will provide milk and blood samples. Researchers will compare mothers with normal weight and with pre-pregnancy overweight/obesity to see if there are differences in child growth and adiposity .

Details

Lead sponsor	Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri
Status	RECRUITING
Enrolment	130
Start date	2019-05-02
Completion	2028-03

Conditions

• Obesity
• Obesity, Infant

Interventions

• overweight/obesity

Primary outcomes

• infant weight — from birth to 2 years old
  weight in kilograms
• infant height — from birth to 2 years old
  height in centimeters
• infant body mass index (BMI) — from birth to 2 years old
  weight and height will be combined to report BMI in kg/m\^2
• infant upper arm circumference — from birth to 2 years old
  upper arm circumference in centimeters
• infant skinfold thickness — from birth to 2 years old
  skinfold thickness in centimeters
• infant blood leptin concentration — six months old
  blood leptin concentration (ng/ml)

Countries

Argentina